Publications

Fusion complexes and CD4-independent gp120s for the induction of HIV-1 neutralizing antibodies  (2005)

Authors:
D. ZIPETO; MATUCCI A; ROSSOLILLO P; RIPAMONTI C; SCARLATTI C; LOPALCO L; HAZAN U; BERTAZZONI U
Title:
Fusion complexes and CD4-independent gp120s for the induction of HIV-1 neutralizing antibodies
Year:
2005
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Language:
Inglese
Format:
Elettronico
Referee:
No
Name of journal:
Retrovirology
ISSN of journal:
1742-4690
N° Volume:
2
Page numbers:
S121-S121
Keyword:
fusion complexes gp120 HIV neutralizing antibodies
Short description of contents:
The narrow spectrum of HIV-specific neutralizing anti- bodies points to the need for new immunogens based on highly conserved epitopes. HIV-1 infects host cells by membrane fusion: during this process conserved epitopes are exposed on the viral glycoprotein gp120/41 that may be used as targets for the induction of antibodies against HIV-1. Neutralizing antibodies against different heterolo- gous HIV-1 isolates may be obtained by immunizing mice with fusion complexes on which conserved epitopes have been stabilized by fixation, or with gp120/41s with a CD4-independent phenotype on which these conserved epitopes may be already exposed.
Web page:
http://www.retrovirology.com/content/2/S1/S121
Product ID:
40293
Handle IRIS:
11562/236864
Deposited On:
June 21, 2012
Last Modified:
March 20, 2018
Bibliographic citation:
D. ZIPETO; MATUCCI A; ROSSOLILLO P; RIPAMONTI C; SCARLATTI C; LOPALCO L; HAZAN U; BERTAZZONI U, Fusion complexes and CD4-independent gp120s for the induction of HIV-1 neutralizing antibodies «Retrovirology» , vol. 22005pp. S121-S121

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