Publications

Transcriptional regulation of the human Raver2 ribonucleoprotein gene.  (2012)

Authors:
Romanelli MG; Lorenzi P; Diani E; Filippello A; Avesani F; Morandi C.
Title:
Transcriptional regulation of the human Raver2 ribonucleoprotein gene.
Year:
2012
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Language:
Inglese
Format:
A Stampa
Referee:
Name of journal:
Gene
ISSN of journal:
0378-1119
N° Volume:
493
:
Elsevier
Page numbers:
243-252
Short description of contents:
Raver2 is a putative modulator of the activity of the polypyrimidine-tract binding protein (PTB), one of the most intensively studied splicing repressors. Little is known about Raver2 expression, and all current data is from mice where it shows tissue specificity. In the present study, by comparing Raver2 transcript expression in human and mouse tissues, we found that human Raver2 is ubiquitously expressed in adult tissues. In order to investigate human Raver2 transcription regulation, we identified and characterized a putative promoter region in a 1000bp region upstream of the transcription starting site of the gene. Dual luciferase reporter assays demonstrated that this region had promoter activity conferred by the first 160bp. By mutagenic analyses of putative cis-acting regulatory sequences, we identified an individual site that decreased the promoter activity by up to 40% when mutated. Together, our results suggest that regulation of human Raver2 expression involves TATA-less transcriptional activity.
Web page:
http://www.ncbi.nlm.nih.gov/pubmed/22146317
Product ID:
66006
Handle IRIS:
11562/390267
Deposited On:
February 21, 2012
Last Modified:
August 28, 2017
Bibliographic citation:
Romanelli MG; Lorenzi P; Diani E; Filippello A; Avesani F; Morandi C., Transcriptional regulation of the human Raver2 ribonucleoprotein gene. «Gene» , vol. 4932012pp. 243-252

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