Publications

Authors:

Bex, F; Avesani, F; Romanelli, Maria; Lodewick, J; Turci, Marco; Sampaio, C; Roger, P; Bertazzoni, Umberto

Title:

Cytoplasmic and nuclear events controllingTax-mediated activation of the NF-kB pathway:involvement of TAB2, IKKgamma/NEMO andcalreticulin

Year:

2011

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

Retrovirology

ISSN of journal:

1742-4690

N° Volume:

8

Number or Folder:

S1

Page numbers:

A138-A138

Keyword:

Tax; HTLV; NF-kB

Short description of contents:

The Tax oncoprotein of HTLV-1 initiates T-cell transformationby dysregulating cell cycle progression andinhibiting DNA damage responses. The subsequentgenomic instability might result in constitutive activationof the NF-B pathway observed in HTLV-1-transformedT lymphocytes. Our previous results indicatedthat differential modifications of Tax by ubiquitinationor sumoylation controlled its retention either in thecytoplasm or in the nucleus, respectively. Here we showthat Tax is targeted to pre-existing punctate cytoplasmicstructures which contain the TNF-receptor associatedprotein 2 (TAB2).

Web page:

http://www.retrovirology.com/content/8/S1/A138

Product ID:

113281

Handle IRIS:

11562/390293

Deposited On:

February 21, 2012

Last Modified:

October 19, 2022

Bibliographic citation:

Bex, F; Avesani, F; Romanelli, Maria; Lodewick, J; Turci, Marco; Sampaio, C; Roger, P; Bertazzoni, Umberto, Cytoplasmic and nuclear events controllingTax-mediated activation of the NF-kB pathway:involvement of TAB2, IKKgamma/NEMO andcalreticulin «Retrovirology» , vol. 8 , n. S1 , 2011 , pp. A138-A138

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