Virus -induced lymphoid neoplasms

Starting date
May 1, 2013
Duration (months)
36
Managers or local contacts
Romanelli Maria
Keyword
HTLV, leukemia, oncoproteins

To gain insight into the mechanism of T-cell transformation, our studies
are focused in understanding the molecular interactions of HTLV and the host,
with particular emphasis on the effects of individual gene products on T-cell
turnover and interaction with microenvironment.

Sponsors:

A.I.R.C. Associazione Italiana per la Ricerca sul Cancro
Funds: assigned and managed by the department
Syllabus: ENTI.RIC - Finanziamento da enti vari per la ricerca
Fondazione Cariverona
Funds: assigned and managed by the department
Syllabus: ENTI.RIC - Finanziamento da enti vari per la ricerca

Project participants

Umberto Bertazzoni
Erica Diani
Temporary Assistant Professor
Maria Romanelli
Associate Professor
Publications
Title Authors Year
Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional Differences. Bertazzoni, U.; Turci, M.; Avesani, F.; DI GENNARO, Gianfranco; Bidoia, C.; Romanelli, Maria 2011
Association of HTLV Tax proteins with TAK1-binding protein 2 and RelA in calreticulin-containing cytoplasmic structures partecipates in Tax-mediated NF-KB activation. Avesani, F.; Romanelli, Maria; Turci, M.; DI GENNARO, Gianfranco; Sampaio, C.; Bidoia, C.; Bertazzoni, U.; Bex, F. 2010
HTLV Tax proteins associate with TAB2 and RelA in Tax-mediated NF-kB activation. Avesani, F.; Romanelli, Maria; Turci, Marco; DI GENNARO, Gianfranco; Sampaio, C.; Bidoia, Carlo; Bex, F.; Bertazzoni, Umberto 2010
Characterization and functional analysis of cis-acting elements of the human farnesyl diphosphate synthetase (FDPS) gene 5' flanking region. Romanelli, Maria; Lorenzi, Pamela; Sangalli, Antonella; Diani, Erica; Mottes, Monica 2009
Functional comparison of Tax proteins of Human T- lymphotropic Viruses -1 and -2: implications for gene transactivation and interaction with signalling pathways. Bertazzoni, Umberto; Turci, Marco; Avesani, F.; Romanelli, Maria; Bex, F. 2009
HTLV-2B Tax oncoprotein is modified by ubiquitination and sumoylation and displays intracellular localization similar to its homologue HTLV-1 Tax. Marco Turci, Julie Lodewick, Paola Righi, Angela Polania, Maria Grazia Romanelli, Françoise Bex, Umberto Bertazzoni 2009
INTERACTIONS OF HTLV TAX ONCOPROTEINS WITH THE p65/RelA FACTOR OF NF-kB PATHWAY. Avesani, Francesca; Lorenzi, Pamela; C., Bidoia; Turci, Marco; Romanelli, Maria; Bertazzoni, Umberto 2008

Activities

Research facilities