Publications

HTLV-2B Tax oncoprotein is modified by ubiquitination and sumoylation and displays intracellular localization similar to its homologue HTLV-1 Tax.  (2009)

Authors:
Marco Turci, Julie Lodewick, Paola Righi, Angela Polania, Maria Grazia Romanelli, Françoise Bex, Umberto Bertazzoni
Title:
HTLV-2B Tax oncoprotein is modified by ubiquitination and sumoylation and displays intracellular localization similar to its homologue HTLV-1 Tax.
Year:
2009
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Nations of authors:
BELGIO; ITALIA
Language:
Inglese
Format:
A Stampa
Referee:
Name of journal:
Virology
ISSN of journal:
0042-6822
N° Volume:
386
Series:
0042-6822
Number or Folder:
1
Page numbers:
6-11
Code PMID:
19195675
Keyword:
HTLV Tax CREB NF-κB Ubiquitination Sumoylation Nuclear bodies
Note:
HTLV-1 is more pathogenic than HTLV-2B. The difference is generally attributed to the properties of their individual transactivating Tax proteins. By using internal Flag-6His tagged Tax-1 and Tax-2B, which display transcriptional activities comparable to the untagged proteins and can be recognized by a single anti-Flag antibody, we demonstrate that Tax-2B is modified by ubiquitination and sumoylation. In addition, Tax2B is distributed in punctuate nuclear structures that include the RelA subunit of NF-kappaB, as has been previously demonstrated for Tax-1.
Product ID:
48907
Handle IRIS:
11562/-327503
Deposited On:
March 1, 2009
Last Modified:
March 1, 2009
Bibliographic citation:
Marco Turci, Julie Lodewick, Paola Righi, Angela Polania, Maria Grazia Romanelli, Françoise Bex, Umberto Bertazzoni, HTLV-2B Tax oncoprotein is modified by ubiquitination and sumoylation and displays intracellular localization similar to its homologue HTLV-1 Tax. «Virology» , vol. 386 , n. 1 0042-68222009pp. 6-11

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