Pubblicazioni

Autori:

Battista, Simone; Buzzatti, Luca; Gandolfi, Marialuisa; Finocchi, Cinzia; Falsiroli Maistrello, Luca; Viceconti, Antonello; Giardulli, Benedetto; Testa, Marco

Titolo:

The use of Botulinum Toxin A as an adjunctive therapy in the management of chronic musculoskeletal pain: a systematic review with meta-analysis

Anno:

2021

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

Sì

Nome rivista:

TOXINS

ISSN Rivista:

2072-6651

N° Volume:

13

Numero o Fascicolo:

640

Intervallo pagine:

1-17

Parole chiave:

botulinum toxins; chronic pain; combined modality therapy; musculoskeletal disease; musculoskeletal pain; physical and rehabilitation medicine; physical therapy modalities; physical therapy specialty; rehabilitation; type A

Breve descrizione dei contenuti:

Several studies have investigated the effect of botulinum toxin A (BoNT-A) for managing chronic musculoskeletal pain, bringing contrasting results to the forefront. Thus far, however, there has been no synthesis of evidence on the effect of BoNT-A as an adjunctive treatment within a multimodal approach. Hence, Medline via PubMed, EMBASE, and the Cochrane Library-CENTRAL were searched until November 2020 for randomised controlled trials (RCTs) that investigated the use of BoNT-A as an adjunctive therapy for chronic musculoskeletal pain. The risk of bias (RoB) and the overall quality of the studies were assessed through RoB 2.0 and the GRADE approach, respectively. Meta-analysis was conducted to analyse the pooled results of the six included RCTs. Four were at a low RoB, while two were at a high RoB. The meta-analysis showed that BoNT-A as an adjunctive therapy did not significantly decrease pain compared to the sole use of traditional treatment (SDM -0.89; 95% CI -1.91; 0.12; p = 0.08). Caution should be used when interpreting such results, since the studies displayed very high heterogeneity (I = 94%, p < 0.001). The overall certainty of the evidence was very low. The data retrieved from this systematic review do not support the use of BoNT-A as an adjunctive therapy in treating chronic musculoskeletal pain.

Pagina Web:

https://doi.org/10.3390/toxins13090640

Id prodotto:

122781

Handle IRIS:

11562/1050160

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Battista, Simone; Buzzatti, Luca; Gandolfi, Marialuisa; Finocchi, Cinzia; Falsiroli Maistrello, Luca; Viceconti, Antonello; Giardulli, Benedetto; Testa, Marco, The use of Botulinum Toxin A as an adjunctive therapy in the management of chronic musculoskeletal pain: a systematic review with meta-analysis «TOXINS» , vol. 13 , n. 640 , 2021 , pp. 1-17

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