Pubblicazioni

Autori:

Savastano, Maria Cristina; Rizzo, Clara; Gambini, Gloria; Savastano, Alfonso; Falsini, Benedetto; Bacherini, Daniela; Caputo, Carmela Grazia; Kilian, Raphael; Faraldi, Francesco; De Vico, Umberto; Rizzo, Stanislao

Titolo:

Choriocapillaris vascular density changes: healthy vs. advanced exudative age-related macular degeneration previously treated with multiple anti-VEGF intravitreal injections

Anno:

2021

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

Sì

Nome rivista:

DIAGNOSTICS

ISSN Rivista:

2075-4418

N° Volume:

11

Numero o Fascicolo:

1958

Intervallo pagine:

1-13

Parole chiave:

OCT angiography; advanced exudative AMD; age-related macular degeneration; biomarkers; innovative biotechnologies; macular neovascularization; personalized medicine

Breve descrizione dei contenuti:

Purpose: To assess choriocapillaris vascular density (VD) in healthy and advanced exudative age-related macular degeneration (ae-AMD) patients by new full-range optical coherence tomography angiography (OCT-A). Method: In this observational, cross-sectional study, 21 healthy and 21 ae-AMD eyes, already treated with anti-VEGF, were enrolled. Angio-View retina patterns centered on fovea (6.4 × 6.4 mm) were acquired for all participants using Solix full-range OCT (Optovue Inc., Freemont, CA, USA). The main outcome was to compare choriocapillaris VD between healthy and ae-AMD eyes. Automated measurements of whole image choriocapillaris VD (%) and fovea grid-based (%) were collected for the analysis. Angio-View patterns were used to assess the flow area (mm2) of macular neovascularization (MNV) by contour flow measure algorithm. Best-corrected visual acuity (BCVA) of both groups was also used for the statistical analysis. Results: The mean age was 60.9 (±8.3) in healthy and 73.33 (±15.05) in ae-AMD eyes. The mean BCVA (ETDRS letters) was 98.47 (±1.50) in healthy and 7.04 (±5.96) in ae-AMD eyes. The Mann-Whitney test comparing choriocapillaries VD for whole and fovea healthy and ae-AMD eyes showed statistical significance (p < 0.0001 (t = 4.91; df = 40) and p < 0.0001 (t = 6.84; df = 40), respectively). Regarding, the correlation between MNV and VD of choriocapillaries, neither whole nor fovea areas were statistically significant (F = 0.38 (R2 = 0.01) and 1.68 (R2 = 0.08), respectively). Conclusions: Choriocapillaris VD showed a statistically significant reduction in comparison to healthy eyes in ae-AMD eyes. Choriocapillaris impairment can be seen in the early phase of MNV pathogenesis.

Pagina Web:

https://www.mdpi.com/2075-4418/11/11/1958#

Id prodotto:

123485

Handle IRIS:

11562/1052982

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Savastano, Maria Cristina; Rizzo, Clara; Gambini, Gloria; Savastano, Alfonso; Falsini, Benedetto; Bacherini, Daniela; Caputo, Carmela Grazia; Kilian, Raphael; Faraldi, Francesco; De Vico, Umberto; Rizzo, Stanislao, Choriocapillaris vascular density changes: healthy vs. advanced exudative age-related macular degeneration previously treated with multiple anti-VEGF intravitreal injections «DIAGNOSTICS» , vol. 11 , n. 1958 , 2021 , pp. 1-13

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo