Pubblicazioni

Autori:

Nasini, Sofia; Tidei, Sara; Shkodra, Atea; De Gregorio, Danilo; Cambiaghi, Marco; Comai, Stefano

Titolo:

Age-related effects of exogenous melatonin on anxiety-like behavior in C57/B6J mice

Anno:

2023

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

Sì

Nome rivista:

BIOMEDICINES

ISSN Rivista:

2227-9059

N° Volume:

11

Numero o Fascicolo:

6

Intervallo pagine:

1-19

Parole chiave:

melatonin; anxiety; mice; adolescents; adults; local field potentials; hippocampus; medial prefrontal cortex; sociability; aging

Breve descrizione dei contenuti:

The synthesis of melatonin (MLT) physiologically decreases during aging. Treatment with MLT has shown anxiolytic, hypnotic, and analgesic effects, but little is known about possible age-dependent differences in its efficacy. Therefore, we studied the effects of MLT (20 mg/kg, intraperitoneal) on anxiety-like behavior (open field (OFT), elevated plus maze (EPMT), three-chamber sociability, and marble-burying (MBT) tests), and the medial prefrontal cortex (mPFC)-dorsal hippocampus (dHippo) circuit in adolescent (35-40 days old) and adult (three-five months old) C57BL/6 male mice. MLT did not show any effect in adolescents in the OFT and EPMT. In adults, compared to vehicles, it decreased locomotor activity and time spent in the center of the arena in the OFT and time spent in the open arms in the EPMT. In the MBT, no MLT effects were observed in both age groups. In the three-chamber sociability test, MLT decreased sociability and social novelty in adults, while it increased sociability in adolescents. Using local field potential recordings, we found higher mPFC-dHippo synchronization in the delta and low-theta frequency ranges in adults but not in adolescents after MLT treatment. Here, we show age-dependent differences in the effects of MLT in anxiety paradigms and in the modulation of the mPFC-dHippo circuit, indicating that when investigating the pharmacology of the MLT system, age can significantly impact the study outcomes.

Pagina Web:

https://doi.org/10.3390/biomedicines11061705

Id prodotto:

134363

Handle IRIS:

11562/1096726

ultima modifica:

28 luglio 2023

Citazione bibliografica:

Nasini, Sofia; Tidei, Sara; Shkodra, Atea; De Gregorio, Danilo; Cambiaghi, Marco; Comai, Stefano, Age-related effects of exogenous melatonin on anxiety-like behavior in C57/B6J mice «BIOMEDICINES» , vol. 11 , n. 6 , 2023 , pp. 1-19

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