Pubblicazioni

Autori:

Antelmi, Elena; Squintani, Giovanna Maddalena; Sandri, Angela; Lippolis, Marianna; Segatti, Alessia; Tinazzi, Michele

Titolo:

Defect of the endogenous inhibitory pain system in idiopathic restless legs syndrome: a laser evoked potentials study

Anno:

2023

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Movement Disorders

ISSN Rivista:

0885-3185

N° Volume:

38

Numero o Fascicolo:

9

Intervallo pagine:

1688-1696

Parole chiave:

laser evoked potentials; neurophysiology; pain system; restless legs syndrome

Breve descrizione dei contenuti:

Background: Restless legs syndrome (RLS) is a complex sensorimotor disorder. Symptoms worsen toward evening and at rest and are temporarily relieved by movement. Symptoms are perceived as painful in up to 45% of cases, and nociception system may be involved. Objectives: To assess the descending diffuse noxious inhibitory control in RLS patients. Methods: Twenty-one RLS patients and twenty age and sex-matched healthy controls (HC) underwent a conditioned pain modulation protocol. Cutaneous heat stimuli were delivered via laser evoked potentials (LEPs) on the dorsum of the right hand (UL) and foot (LL). N2 and P2 latencies, N2/P2 amplitude and pain ratings (NRS) were recorded before (baseline), during, and after a heterotopic noxious conditioning stimulation (HNCS) application. The baseline/HNCS ratio was calculated for both UL and LL. Results: N2 and P2 latencies did not vary between groups at each condition and limbs. Both groups showed a physiological N2/P2 amplitude and NRS reduction during the HNCS condition in UL and LL in comparison to baseline and post conditions (all, P < 0.003). Between-groups comparisons revealed a significant lower amplitude reduction in RLS at the N2/P2 amplitude during the HNCS condition only for LL (RLS, 13.6 μV; HC, 10.1 μV; P = 0.004). Such result was confirmed by the significant difference at the ratio (RLS, 69%, HC, 52.5%; P = 0.038). Conclusions: The lower physiological reduction during the HNCS condition at LL in RLS patients suggests a defect in the endogenous inhibitory pain system. Further studies should clarify the causal link of this finding, also investigating the circadian modulation of this paradigm. © 2023 International Parkinson and Movement Disorder Society.

Pagina Web:

https://doi.org/10.1002/mds.29509

Id prodotto:

134388

Handle IRIS:

11562/1096826

ultima modifica:

11 novembre 2023

Citazione bibliografica:

Antelmi, Elena; Squintani, Giovanna Maddalena; Sandri, Angela; Lippolis, Marianna; Segatti, Alessia; Tinazzi, Michele, Defect of the endogenous inhibitory pain system in idiopathic restless legs syndrome: a laser evoked potentials study «Movement Disorders» , vol. 38 , n. 9 , 2023 , pp. 1688-1696

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