Pubblicazioni

Autori:

Aprea, Maria Grazia; Schiavetti, Irene; Portaccio, Emilio; Ballerini, Chiara; Bonavita, Simona; Buscarinu, Maria; Calabrese, Massimiliano; Cavalla, Paola; Cellerino, Maria; Cordioli, Cinzia; Dattola, Vincenzo; De Biase, Stefano; De Meo, Ermelinda; Fantozzi, Roberta; Gallo, Antonio; Iasevoli, Luigi; Karabudak, Rana; Landi, Doriana; Lorefice, Lorena; Moiola, Lucia; Ragonese, Paolo; Ruscica, Francesca; Sen, Sedat; Sinisi, Leonardo; Signoriello, Elisabetta; Toscano, Simona; Verrengia, Elena; Siva, Aksel; Masciulli, Camilla; Sormani, Maria Pia; Amato, Maria Pia

Titolo:

Impact of COVID-19 on pregnancy and fetal outcomes in women with multiple sclerosis

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Multiple Sclerosis

ISSN Rivista:

1352-4585

N° Volume:

36

Numero o Fascicolo:

6

Intervallo pagine:

707-713

Parole chiave:

COVID-19; Multiple sclerosis; SARS-CoV-2 infection; fetal outcomes; maternal outcomes; pregnancy

Breve descrizione dei contenuti:

Background: In the general population, maternal COVID-19 is associated with worse maternal and fetal outcomes. Two previous studies have assessed COVID-19 clinical outcomes in pregnant women with multiple sclerosis (MS), but there are no data about maternal and fetal outcomes. Objectives: In this multicenter study, we aimed to assess maternal and fetal outcomes in pregnant women with MS and COVID-19 infection. Methods: We recruited pregnant patients with MS who contracted COVID-19 and were followed up in Italian and Turkish Centers, during 2020-2022. A control group was extracted from a previous Italian cohort. Associations between group (COVID-19 or healthy patients) and clinical outcomes (maternal complications, fetal malformations, and spontaneous abortion) were investigated with a weighted logistic regression where propensity score-based inverse probability of treatment weighting (IPTW) approach was applied for adjusting for difference in baseline confounders. Results: In the multivariable analysis, COVID-19 during pregnancy was associated with a higher risk of maternal complications (odd ratio (OR) = 2.12; 95% confidence interval (CI) = 1.32-3.48; p = 0.002), while it was not associated with higher risk of spontaneous abortion and fetal malformations. Conclusion: Our data indicate that COVID-19 during pregnancy increases the risk of maternal complications, while it seems to have no significant impact on fetal outcomes.

Pagina Web:

https://doi.org/10.1177/13524585241232266

Id prodotto:

138502

Handle IRIS:

11562/1121779

ultima modifica:

29 maggio 2024

Citazione bibliografica:

Aprea, Maria Grazia; Schiavetti, Irene; Portaccio, Emilio; Ballerini, Chiara; Bonavita, Simona; Buscarinu, Maria; Calabrese, Massimiliano; Cavalla, Paola; Cellerino, Maria; Cordioli, Cinzia; Dattola, Vincenzo; De Biase, Stefano; De Meo, Ermelinda; Fantozzi, Roberta; Gallo, Antonio; Iasevoli, Luigi; Karabudak, Rana; Landi, Doriana; Lorefice, Lorena; Moiola, Lucia; Ragonese, Paolo; Ruscica, Francesca; Sen, Sedat; Sinisi, Leonardo; Signoriello, Elisabetta; Toscano, Simona; Verrengia, Elena; Siva, Aksel; Masciulli, Camilla; Sormani, Maria Pia; Amato, Maria Pia, Impact of COVID-19 on pregnancy and fetal outcomes in women with multiple sclerosis «Multiple Sclerosis» , vol. 36 , n. 6 , 2024 , pp. 707-713

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo