Pubblicazioni

Autori:

Calabrese, Massimiliano; Preziosa, Paolo; Scalfari, Antonio; Colato, Elisa; Marastoni, Damiano; Absinta, Martina; Battaglini, Marco; De Stefano, Nicola; Di Filippo, Massimiliano; Hametner, Simon; Howell, Owain W; Inglese, Matilde; Lassmann, Hans; Martin, Roland; Nicholas, Richard; Reynolds, Richard; Rocca, Maria A; Tamanti, Agnese; Vercellino, Marco; Villar, Luisa Maria; Filippi, Massimo; Magliozzi, Roberta

Titolo:

Determinants and Biomarkers of Progression Independent of Relapses in Multiple Sclerosis

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Annals of Neurology

ISSN Rivista:

0364-5134

N° Volume:

First published online: 03 April 2024

Intervallo pagine:

1-20

Parole chiave:

multiple sclerosis (MS); clinical and radiological relapses (PIRA); early biomarkers; clinical practice

Breve descrizione dei contenuti:

Clinical, pathological, and imaging evidence in multiple sclerosis (MS) suggests that a smoldering inflammatory activity is present from the earliest stages of the disease and underlies the progression of disability, which proceeds relentlessly and independently of clinical and radiological relapses (PIRA). The complex system of pathological events driving "chronic" worsening is likely linked with the early accumulation of compartmentalized inflammation within the central nervous system as well as insufficient repair phenomena and mitochondrial failure. These mechanisms are partially lesion-independent and differ from those causing clinical relapses and the formation of new focal demyelinating lesions; they lead to neuroaxonal dysfunction and death, myelin loss, glia alterations, and finally, a neuronal network dysfunction outweighing central nervous system (CNS) compensatory mechanisms. This review aims to provide an overview of the state of the art of neuropathological, immunological, and imaging knowledge about the mechanisms underlying the smoldering disease activity, focusing on possible early biomarkers and their translation into clinical practice. ANN NEUROL 2024.

Pagina Web:

https://doi.org/10.1002/ana.26913

Id prodotto:

138925

Handle IRIS:

11562/1124174

ultima modifica:

12 giugno 2024

Citazione bibliografica:

Calabrese, Massimiliano; Preziosa, Paolo; Scalfari, Antonio; Colato, Elisa; Marastoni, Damiano; Absinta, Martina; Battaglini, Marco; De Stefano, Nicola; Di Filippo, Massimiliano; Hametner, Simon; Howell, Owain W; Inglese, Matilde; Lassmann, Hans; Martin, Roland; Nicholas, Richard; Reynolds, Richard; Rocca, Maria A; Tamanti, Agnese; Vercellino, Marco; Villar, Luisa Maria; Filippi, Massimo; Magliozzi, Roberta, Determinants and Biomarkers of Progression Independent of Relapses in Multiple Sclerosis «Annals of Neurology» , vol. First published online: 03 April 2024 , 2024 , pp. 1-20

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo