Pubblicazioni

Autori:

Dolci, Sissi; Mannino, Loris; Campanelli, Alessandra; Rossi, Eros; Bottani, Emanuela; Ciarpella, Francesca; Karkossa, Isabel; Setten, Elisa; Savino, Benedetta; Pruonto, Giulia; Piazza, Nicola; Gianoli, Stefano; Amenta, Alessia; Busetto, Giuseppe; Pezzotta, Alex; DI CHIO, Marzia; Castagna, Alessandra; Martinelli, Nicolò; Barone, Ilaria; Boschi, Federico; Doherty, Adam; Scupoli, Maria; Cavallini, Chiara; Malpeli, Giorgio; Malik, Zulkifal; Sagripanti, Ludovica; Silani, Vincenzo; Cristofori, Patrizia; Scanziani, Eugenio; Sandri, Marco; Pistocchi, Anna; Bossolasco, Patrizia; Endrizzi, Marco; Schubert, Kristin; Fumagalli, Guido Francesco; Locati, Massimo; Bifari, Francesco; Decimo, Ilaria

Titolo:

Tumor-associated macrophages enhance tumor innervation and spinal cord repair

Anno:

2024

Tipologia prodotto:

Rapporti di ricerca

Tipologia ANVUR:

Altro

Lingua:

Inglese

Formato:

Elettronico

Parole chiave:

Tumor associated macrophages, ECM components, intratumoral nerve growth

Breve descrizione dei contenuti:

Tumor-associated macrophages (TAM) enhance cancer progression by promoting angiogenesis, extracellular matrix (ECM) remodeling, and immune suppression. Nerve infiltration is a hallmark of various cancers and is known to directly contribute to tumor growth. However, the role of TAM in promoting intratumoral nerve growth remains poorly understood. In this study, we demonstrate that TAM expressed a distinct “neural growth” gene signature. TAM actively enhance neural growth within tumors and directly promote neurites outgrowth. We identify secreted phosphoprotein 1 (Spp1) as a key mediator of TAM-driven neural growth activity, which triggers neuronal mTORC2 signaling. Leveraging this new neural growth function, which added to the TAM wound healing properties, we explored TAM potential to repair central nervous system. Adoptive transfer of in vitro-generated TAM in a severe complete-compressive-contusive spinal cord injury (scSCI) model, not only repaired the damaged neural parenchyma by improving tissue oxygenation, ECM remodeling, and dampening chronic inflammation, but also resulted in neural regrowth and partial functional motor recovery. Proteomic analysis and subsequent functional validation confirmed that TAM-induced spinal cord regeneration is mediated through the activation of neural mTORC2 signaling pathways. Collectively, our data unveil a previously unrecognized role of TAM in tumor innervation, neural growth, and neural tissue repair.

Pagina Web:

https://doi.org/10.1101/2024.12.19.629374

Dipartimento:

Id prodotto:

144471

Handle IRIS:

11562/1155891

ultima modifica:

28 febbraio 2025

Citazione bibliografica:

Dolci, Sissi; Mannino, Loris; Campanelli, Alessandra; Rossi, Eros; Bottani, Emanuela; Ciarpella, Francesca; Karkossa, Isabel; Setten, Elisa; Savino, Benedetta; Pruonto, Giulia; Piazza, Nicola; Gianoli, Stefano; Amenta, Alessia; Busetto, Giuseppe; Pezzotta, Alex; DI CHIO, Marzia; Castagna, Alessandra; Martinelli, Nicolò; Barone, Ilaria; Boschi, Federico; Doherty, Adam; Scupoli, Maria; Cavallini, Chiara; Malpeli, Giorgio; Malik, Zulkifal; Sagripanti, Ludovica; Silani, Vincenzo; Cristofori, Patrizia; Scanziani, Eugenio; Sandri, Marco; Pistocchi, Anna; Bossolasco, Patrizia; Endrizzi, Marco; Schubert, Kristin; Fumagalli, Guido Francesco; Locati, Massimo; Bifari, Francesco; Decimo, Ilaria, Tumor-associated macrophages enhance tumor innervation and spinal cord repair, Dipartimento Biotecnologie,  N°  , 2024

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo