Publications

Association of HTLV Tax proteins with TAK1-binding protein 2 and RelA in calreticulin-containing cytoplasmic structures partecipates in Tax-mediated NF-KB activation.  (2010)

Authors:
Avesani F.; Romanelli MG.; Turci M.; Di Gennaro G.; Sampaio C.; Bidoia C.; Bertazzoni U.; Bex F.
Title:
Association of HTLV Tax proteins with TAK1-binding protein 2 and RelA in calreticulin-containing cytoplasmic structures partecipates in Tax-mediated NF-KB activation.
Year:
2010
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Language:
Inglese
Format:
A Stampa
Referee:
Name of journal:
Virology
ISSN of journal:
0042-6822
N° Volume:
408
Number or Folder:
1
Page numbers:
39-48
Keyword:
Calreticulin; HTLV; NF-κB; RelA; Signalling; TAB2; Tax; Transactivation;
Short description of contents:
HTLV-1 is more pathogenic than HTLV-2 despite having a similar genome and closely related transactivating oncoproteins. Both Tax-1 protein from HTLV-1 and Tax-2 from HTLV-2 activate the NF-κB pathway. The mechanisms involved in Tax-1 deregulation of this signalling pathway have been thoroughly investigated, but little is known about regulation by Tax-2. We have compared the interaction of Tax-1 and Tax-2 with two key NF-κB signalling factors: TAK1-binding protein 2 (TAB2), an adaptor involved in the activation of TAK1 kinase, and RelA, the active subunit of the canonical RelA/p50 NF-κB transcription factor. Tax-2 formed stable complexes with both RelA and TAB2. These two NF-κB factors colocalized with Tax proteins in dotted cytoplasmic structures targeted by calreticulin, a multi-process calcium-buffering chaperone. Co-expression of RelA and/or TAB2 markedly increased Tax-mediated NF-κB activation. These findings provide new insights into the role of RelA, TAB2 and Tax in the deregulation of the NF-κB pathway.
Web page:
http://www.ncbi.nlm.nih.gov/pubmed/20875659
Product ID:
60582
Handle IRIS:
11562/352798
Deposited On:
February 21, 2012
Last Modified:
August 26, 2021
Bibliographic citation:
Avesani F.; Romanelli MG.; Turci M.; Di Gennaro G.; Sampaio C.; Bidoia C.; Bertazzoni U.; Bex F., Association of HTLV Tax proteins with TAK1-binding protein 2 and RelA in calreticulin-containing cytoplasmic structures partecipates in Tax-mediated NF-KB activation. «Virology» , vol. 408 , n. 12010pp. 39-48

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