Publications

Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional Differences.  (2011)

Authors:
Bertazzoni U.; Turci M.; Avesani F.; Di Gennaro G.; Bidoia C.; Romanelli MG.
Title:
Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional Differences.
Year:
2011
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Language:
Inglese
Format:
Elettronico
Referee:
Name of journal:
VIRUSES
ISSN of journal:
1999-4915
N° Volume:
3
Number or Folder:
5
Page numbers:
541-560
Keyword:
HTLV; Tax-1; Tax-2; signal transduction; cellular localization; post-translational modifications; NF-κB; PDZ binding motif
Short description of contents:
Human T-lymphotropic viruses type 1 (HTLV-1) and type 2 (HTLV-2) present very similar genomic structures but HTLV-1 is more pathogenic than HTLV-2. Is this difference due to their transactivating Tax proteins, Tax-1 and Tax-2, which are responsible for viral and cellular gene activation? Do Tax-1 and Tax-2 differ in their cellular localization and in their interaction pattern with cellular factors? In this review, we summarize Tax-1 and Tax-2 structural and phenotypic properties, their interaction with factors involved in signal transduction and their localization-related behavior within the cell. Special attention will be given to the distinctions between Tax-1 and Tax-2 that likely play an important role in their transactivation activity.
Web page:
http://www.ncbi.nlm.nih.gov/pubmed
Product ID:
63738
Handle IRIS:
11562/373052
Deposited On:
November 14, 2011
Last Modified:
August 16, 2021
Bibliographic citation:
Bertazzoni U.; Turci M.; Avesani F.; Di Gennaro G.; Bidoia C.; Romanelli MG., Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional Differences. «VIRUSES» , vol. 3 , n. 52011pp. 541-560

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