- Authors:
-
Bertazzoni, U.; Turci, M.; Avesani, F.; DI GENNARO, Gianfranco; Bidoia, C.; Romanelli, Maria
- Title:
-
Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional Differences.
- Year:
-
2011
- Type of item:
-
Articolo in Rivista
- Tipologia ANVUR:
- Articolo su rivista
- Language:
-
Inglese
- Format:
-
Elettronico
- Referee:
-
Sì
- Name of journal:
- VIRUSES
- ISSN of journal:
- 1999-4915
- N° Volume:
-
3
- Number or Folder:
-
5
- Page numbers:
-
541-560
- Keyword:
-
HTLV; Tax-1; Tax-2; signal transduction; cellular localization; post-translational modifications; NF-κB; PDZ binding motif
- Short description of contents:
- Human T-lymphotropic viruses type 1 (HTLV-1) and type 2 (HTLV-2) present very similar genomic structures but HTLV-1 is more pathogenic than HTLV-2. Is this difference due to their transactivating Tax proteins, Tax-1 and Tax-2, which are responsible for viral and cellular gene activation? Do Tax-1 and Tax-2 differ in their cellular localization and in their interaction pattern with cellular factors? In this review, we summarize Tax-1 and Tax-2 structural and phenotypic properties, their interaction with factors involved in signal transduction and their localization-related behavior within the cell. Special attention will be given to the distinctions between Tax-1 and Tax-2 that likely play an important role in their transactivation activity.
- Web page:
-
http://www.ncbi.nlm.nih.gov/pubmed
- Product ID:
-
63738
- Handle IRIS:
-
11562/373052
- Deposited On:
-
November 14, 2011
- Last Modified:
-
November 15, 2022
- Bibliographic citation:
-
Bertazzoni, U.; Turci, M.; Avesani, F.; DI GENNARO, Gianfranco; Bidoia, C.; Romanelli, Maria,
Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional Differences.
«VIRUSES»
, vol.
3
, n.
5
,
2011
,
pp. 541-560
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