Pubblicazioni

Autori:

Ostuzzi, Giovanni; Mazzi, Maria Angela; Terlizzi, Samira; Bertolini, Federico; Aguglia, Andrea; Bartoli, Francesco; Bortolaso, Paola; Callegari, Camilla; Caroleo, Mariarita; Carrà, Giuseppe; Corbo, Mariangela; D'Agostino, Armando; Gastaldon, Chiara; Lucii, Claudio; Magliocco, Fabio; Martinotti, Giovanni; Nosé, Michela; Ostinelli, Edoardo Giuseppe; Papola, Davide; Piccinelli, Marco Piero; Piccoli, Alberto; Purgato, Marianna; Tabacchi, Tommaso; Turrini, Giulia; Ruggeri, Mirella; Barbui, Corrado

Titolo:

Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy

Anno:

2018

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

Sì

Nome rivista:

PLoS ONE

ISSN Rivista:

1932-6203

N° Volume:

13

Numero o Fascicolo:

8

Intervallo pagine:

e0201371-17

Parole chiave:

long-acting intramuscular (LAI) antipsychotics; clinical practice; assessment; second-generation antipsychotic (SGA) LAIs

Breve descrizione dei contenuti:

BACKGROUND: For many years, long-acting intramuscular (LAI) antipsychotics have been prescribed predominantly to chronic and severe patients, as a last resort when other treatments failed. Recently, a broader and earlier use of LAIs, particularly second-generation LAIs, has been emphasized. To date, few studies attempted to frame how this change in prescribing took place in real-world practice. Therefore, this study aimed to describe the clinical features of patients prescribed with LAIs, and to explore possible prescribing differences between first- and second-generations LAIs under ordinary clinical practice in Italy. METHODS: The STAR Network "Depot" Study is an observational, longitudinal, multicenter study involving 35 centers in Italy. In the cross-sectional phase, patients prescribed with LAIs were consecutively recruited and assessed over a period of 12 months. Descriptive statistics and multivariable logistic regression analyses were employed. RESULTS: Of the 451 recruited patients, 61% were males. The level of social and working functioning was heterogeneous, as was the severity of disease. Seventy-two per cent of the patients had a diagnosis of the schizophrenia spectrum. Seventy per cent were prescribed with second-generation antipsychotic (SGA) LAIs (mostly paliperidone, aripiprazole and risperidone). Compared to first-generation antipsychotic (FGA) LAIs, patients prescribed with SGA LAIs were more often younger; employed; with a diagnosis of the schizophrenia spectrum or bipolar disorder; with higher levels of affective symptoms; with fewer LAI prescriptions in the past. DISCUSSION: LAIs' prescribing practices appear to be more flexible as compared to the past, although this change is mostly restricted to SGA LAIs.

Pagina Web:

https://doi.org/10.1371/journal.pone.0201371

Id prodotto:

103922

Handle IRIS:

11562/984129

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Ostuzzi, Giovanni; Mazzi, Maria Angela; Terlizzi, Samira; Bertolini, Federico; Aguglia, Andrea; Bartoli, Francesco; Bortolaso, Paola; Callegari, Camilla; Caroleo, Mariarita; Carrà, Giuseppe; Corbo, Mariangela; D'Agostino, Armando; Gastaldon, Chiara; Lucii, Claudio; Magliocco, Fabio; Martinotti, Giovanni; Nosé, Michela; Ostinelli, Edoardo Giuseppe; Papola, Davide; Piccinelli, Marco Piero; Piccoli, Alberto; Purgato, Marianna; Tabacchi, Tommaso; Turrini, Giulia; Ruggeri, Mirella; Barbui, Corrado, Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy «PLoS ONE» , vol. 13 , n. 8 , 2018 , pp. e0201371-17

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