Pubblicazioni

Autori:

Baldin, Elisa; Riise, Trond; Mattarozzi, Katia; Gajofatto, Alberto; Granella, Franco; Leone, Maurizio; Lugaresi, Alessandra; Malagù, Susanna; Motti, Luisa; Neri, Walter; Pesci, Ilaria; Santangelo, Mario; Scandellari, Cinzia; Tola, Maria Rosaria; Vignatelli, Luca; Zenesini, Corrado; D'Alessandro, Roberto

Titolo:

Health-related quality of life in clinically isolated syndrome and risk of conversion to multiple sclerosis

Anno:

2019

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

NEUROLOGICAL SCIENCES

ISSN Rivista:

1590-1874

N° Volume:

40

Numero o Fascicolo:

1

Intervallo pagine:

75-80

Parole chiave:

Clinically isolated syndrome (CIS); Multiple sclerosis; Prognostic factors; Prospective study; Quality of life; Self-rated health

Breve descrizione dei contenuti:

BACKGROUND AND OBJECTIVES: A few studies have found that low scores on self-rated health and quality of life measures are associated with following worsening disability in multiple sclerosis (MS). We wanted to estimate the association between self-rated quality of life scores among patients with clinically isolated syndrome (CIS) and the risk of subsequent conversion to definite MS. METHODS: One hundred sixty-two patients from the GERONIMUS cohort with a symptom or sign suggestive of MS and without a definite diagnosis of MS at the time of inclusion were asked to evaluate their health-related quality of life according to MSQoL-54 scale. They were clinically assessed and mood and depression scales were applied. The association between the scores of these scales and the risk of converting to definite MS during a 5-year follow-up was estimated using the Cox- proportional hazard regression model. RESULTS: Quality of life at examination was significantly lower compared to those of an age- and sex-adjusted general Italian population. During the follow-up, 116 patients (72%) converted to definite MS. No significant predictive effects were found for the summary scales of MSQol-54 or other scales. The estimates did not change after adjusting for age, sex, BMI, education, MRI findings, Expanded Disability Status Scale (EDSS) score, and treatment at time of examination. CONCLUSION: Persons with CIS in this cohort reported reduced self-rated quality of life compared to the general population, but variation in these scores was not associated with subsequent conversion from CIS to clinical definite MS.

Pagina Web:

https://doi.org/10.1007/s10072-018-3582-0

Id prodotto:

104357

Handle IRIS:

11562/985812

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Baldin, Elisa; Riise, Trond; Mattarozzi, Katia; Gajofatto, Alberto; Granella, Franco; Leone, Maurizio; Lugaresi, Alessandra; Malagù, Susanna; Motti, Luisa; Neri, Walter; Pesci, Ilaria; Santangelo, Mario; Scandellari, Cinzia; Tola, Maria Rosaria; Vignatelli, Luca; Zenesini, Corrado; D'Alessandro, Roberto, Health-related quality of life in clinically isolated syndrome and risk of conversion to multiple sclerosis «NEUROLOGICAL SCIENCES» , vol. 40 , n. 1 , 2019 , pp. 75-80

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