In this project we foresee to investigate the still largely unexplored role of the cytoskeletal regulator Rho-GTPases in Alzheimer’s Disease (AD). The main question we would like to address are the following: - are Rho-GTPases directly mediating beta-amyloid peptide toxicity? - - Can the modulation of Rho-GTPases family members reverse AD-related neuropathology? - Is it possibile to correlate a different pattern of Rho-GTPases expression to different AD phenotype? Thus, the focus of this project, using a wide range of models and cutting edge technologies, is to evaluate whether Rho-GTPases alteration may be revelant to AD etiopathogenesis or whether the potential alteration of this family of proteins is only ancillary to the disorder, representing an aspect of a general neurodegenerative mechanism.