Pubblicazioni

Post-transcriptional Gene Regulation: Role of the Polypyrimidine Tract-binding Protein (PTB) and Associated Factors in "From the hallowed halls of Herpesvirology".  (2012)

Autori:
Romanelli MG.; Diani E.
Titolo:
Post-transcriptional Gene Regulation: Role of the Polypyrimidine Tract-binding Protein (PTB) and Associated Factors in "From the hallowed halls of Herpesvirology".
Anno:
2012
Tipologia prodotto:
Monografia o trattato scientifico
Tipologia ANVUR:
Monografia o trattato scientifico
Nazioni degli autori:
ITALIA
Lingua:
Inglese
Formato:
A Stampa
Casa editrice:
John A. Blaho, Joel Baines
ISBN:
9789814338981
Parole chiave:
Ribonucleoproteins, gene expression regulation, polypyrimidine-tract binding protein
Breve descrizione dei contenuti:
The overall processes of gene expression, from mRNA biogenesis to translation and degradation, require RNA messenger ribonucleoprotein (mRNP) complexes assembly, differentially combined with individual transcripts in order to mediate the post-transcriptional events. One of those events, the alternative splicing of pre-mRNA, is responsible for the wide variety and complexity levels of transcriptome and proteome. Large-scale expressed sequence tag and genome-wide analyses estimate that more than 60% of human genes undergo alternative splicing with a differential tissue distribution. More than 15% of human genetic diseases are associated to mutations in the consensus splice sites and disruption of splicing regulatory networks contributes to various diseases, including cancer. Among the best characterized splicing regulators is the polypyrimidine tract binding protein (PTB) and its paralog nPTB. Highly conserved in vertebrates, PTB has been implicated in several cellular process related to post-transcriptional regulation. In addition to the alternative splicing regulation, PTB is involved into polyadenylation, mRNA stability and initiation of translation. For the latter, several studies have described the PTB recruitment in IRES-mediated translation initiation or propagation of several viruses including hepatitis C virus and picornaviruses. To perform these functions PTB is regulated in its intracellular localization, shuttling between nucleus and cytoplasm. Tissue specific PTB isoforms and co-regulators, the ribonucleoproteins Raver 1 and 2, have been recently identified. Mechanisms of post-transcriptional regulation mediated by PTB, nPTB and Raver proteins are described in the present review.
Id prodotto:
63739
Handle IRIS:
11562/373054
depositato il:
24 febbraio 2012
ultima modifica:
2 novembre 2016
Citazione bibliografica:
Romanelli MG.; Diani E., Post-transcriptional Gene Regulation: Role of the Polypyrimidine Tract-binding Protein (PTB) and Associated Factors in "From the hallowed halls of Herpesvirology".John A. Blaho, Joel Baines2012

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo IRIS

Progetti Collegati
Titolo Dipartimento Responsabili
<<indietro

Attività

Strutture