Cause evoluzione e progressione dei polipi nasali: ruolo di geni modificatori e nuovi approcci con CGH-array

Starting date
September 1, 2006
Duration (months)
24
Managers or local contacts
Pignatti Pierfranco

We want focus our attention to an extended genetic characterization of CFTR to search mutations and/or variant tracts with a well-established pathogenetic role (first kind of molecular lesion), and to investigate the presence of intronic and silent-exonic genomic variants whose functional relevance is to be assessed (second kind of molecular lesion). Concerning the third kind of molecular lesion, we want to determine if the development of nasal polyposis can be related to the expression of the SPINK5, and/or to structural or functional mutations in these genes. The fourth aim of this project wants to improve our knowledge of somatic DNA alterations (fourth kind of molecular lesion) in the nasal polyposis evolution through CGH array.

Sponsors:

Fondazione per la Ricerca sulla Fibrosi Cistica - Onlus
Funds: assigned and managed by the department
Syllabus: ENTI.RIC - Finanziamento da enti vari per la ricerca

Project participants

Francesca Belpinati
Technical-administrative staff
Cristina Bombieri
Associate Professor
Giovanni Malerba
Full Professor
Cristina Patuzzo
Technical-administrative staff
Pierfranco Pignatti

Collaboratori esterni

Giuseppe Novelli
Università Roma Tor Vergata
Roberto Strom
Sapienza Università Roma - Policlinico umberto I
Marco Lucarelli
Sapienza - Roma professore associato

Activities

Research facilities