MOLECULAR AND FUNCTIONAL STUDY OF THE EPITHELIAL Na+ CHANNEL (ENaC) IN CF AND CF-LIKE DISEASE

Starting date
September 15, 2010
Duration (months)
12
Managers or local contacts
Bombieri Cristina

Explore whether molecular defects and transcriptional alterations in the genes encoding for ENaC subunits (SCNN1A, B, and G genes), possibly associated to CFTR gene mutations, could be the cause of CF and CF-like disease. To this purpose, the SCNN1A, SCNN1B, SCNN1G genes are analysed at mutational and transcriptional control level, including biological and functional analysis.

Sponsors:

Fondazione per la Ricerca sulla Fibrosi Cistica - Onlus
Funds: assigned and managed by the department
Syllabus: ENTI.RIC - Finanziamento da enti vari per la ricerca

Project participants

Francesca Belpinati
Technical-administrative staff
Cristina Bombieri
Associate Professor
Anna Rita Lo Presti
Pierfranco Pignatti

Collaboratori esterni

Marco Lucarelli
Sapienza - Roma professore associato
Manuela Seia
Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, MI Laboratorio di Genetica Molecolare
Fiorentina Ascenzioni
Sapienza Università Roma
Massimo Conese
Univeristà Foggia

Activities

Research facilities