Virus -induced lymphoid neoplasms

Starting date
May 1, 2013
Duration (months)
36
Managers or local contacts
Romanelli Maria
Keyword
HTLV, leukemia, oncoproteins

To gain insight into the mechanism of T-cell transformation, our studies
are focused in understanding the molecular interactions of HTLV and the host,
with particular emphasis on the effects of individual gene products on T-cell
turnover and interaction with microenvironment.

Sponsors:

A.I.R.C. Associazione Italiana per la Ricerca sul Cancro
Funds: assigned and managed by the department
Syllabus: ENTI.RIC - Finanziamento da enti vari per la ricerca
Fondazione Cariverona
Funds: assigned and managed by the department
Syllabus: ENTI.RIC - Finanziamento da enti vari per la ricerca

Project participants

Maria Romanelli
Associate Professor
Publications
Title Authors Year
Comparison of Tax-1 and Tax-2B posttranslational modifications using specific lysine mutants in relation to activation of NF-B and intracellular localization Turci M, Di Gennaro G, Cotena A, Marin O, Avesani F, Cremonese G, Diani E, Romanelli MG, Bertazzoni U. 2011
Cytoplasmic and nuclear events controlling Tax-mediated activation of the NF-kB pathway: involvement of TAB2, IKKgamma/NEMO and calreticulin Bex F, Avesani F, Romanelli MG, Lodewick J, Turci M, Sampaio C, Roger P, Bertazzoni U 2011
IKKepsilon involvement in Tax-mediated activation of INF pathway Cremonese G, Avesani F, Diani E, Turci M, Di Gennaro G, Bertazzoni U, Romanelli MG 2011
Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional Differences. Bertazzoni U.; Turci M.; Avesani F.; Di Gennaro G.; Bidoia C.; Romanelli MG. 2011
Association of HTLV Tax proteins with TAK1-binding protein 2 and RelA in calreticulin-containing cytoplasmic structures partecipates in Tax-mediated NF-KB activation. Avesani F.; Romanelli MG.; Turci M.; Di Gennaro G.; Sampaio C.; Bidoia C.; Bertazzoni U.; Bex F. 2010
HTLV Tax proteins associate with TAB2 and RelA in Tax-mediated NF-kB activation. Avesani F.; Romanelli M.G.; Turci M.; Di Gennaro G.; Sampaio C.; Bidoia C.; Bex F.; Bertazzoni U. 2010
Characterization and functional analysis of cis-acting elements of the human farnesyl diphosphate synthetase (FDPS) gene 5' flanking region. Romanelli, Maria; Lorenzi, Pamela; Sangalli, Antonella; Diani, Erica; Mottes, Monica 2009
Functional comparison of Tax proteins of Human T- lymphotropic Viruses -1 and -2: implications for gene transactivation and interaction with signalling pathways. Bertazzoni U.; Turci M.; Avesani F.; Romanelli M.G.; Bex F. 2009
HTLV-2B Tax oncoprotein is modified by ubiquitination and sumoylation and displays intracellular localization similar to its homologue HTLV-1 Tax. Marco Turci, Julie Lodewick, Paola Righi, Angela Polania, Maria Grazia Romanelli, Françoise Bex, Umberto Bertazzoni 2009
INTERACTIONS OF HTLV TAX ONCOPROTEINS WITH THE p65/RelA FACTOR OF NF-kB PATHWAY. F. Avesani; P. Lorenzi; C. Bidoia; M. Turci; M. G. Romanelli; U. Bertazzoni. 2008

Activities

Research facilities