The role of the Rho-GTPase proteins in the aetiology of Alzheimer’s disease - Bando Ricerca Finalizzata anno 2011

Starting date
December 1, 2014
Duration (months)
36
Departments
Neurosciences, Biomedicine and Movement Sciences
Managers or local contacts
Borin Mirta

In this project we foresee to investigate the still largely unexplored role of the cytoskeletal regulator Rho-GTPases in Alzheimer’s Disease (AD). The main question we would like to address are the following: - are Rho-GTPases directly mediating beta-amyloid peptide toxicity? - - Can the modulation of Rho-GTPases family members reverse AD-related neuropathology? - Is it possibile to correlate a different pattern of Rho-GTPases expression to different AD phenotype? Thus, the focus of this project, using a wide range of models and cutting edge technologies, is to evaluate whether Rho-GTPases alteration may be revelant to AD etiopathogenesis or whether the potential alteration of this family of proteins is only ancillary to the disorder, representing an aspect of a general neurodegenerative mechanism.

Sponsors:

Ministero della Salute
Funds: assigned and managed by the department

Project participants

Collaboratori esterni

Silvia Bolognin
IRCCS Centro San Giovanni di Dio Fatebenefratelli
Marcella Catania
Fondazione IRCCS Istituto Neurologico C.Besta

Activities

Research facilities