Pubblicazioni

Autori:

Mattioli, Flavia; Bellomi, F; Stampatori, C; Mariotto, S; Ferrari, S; Monaco, S; Mancinelli, C; Capra, R

Titolo:

Longitudinal serum neurofilament light chain (sNfL) concentration relates to cognitive function in multiple sclerosis patients

Anno:

2020

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Journal of Neurology

ISSN Rivista:

0340-5354

N° Volume:

267

Numero o Fascicolo:

8

Intervallo pagine:

2245-2251

Parole chiave:

Cognitive impairment; Longitudinal; Multiple sclerosis; Neurofilaments

Breve descrizione dei contenuti:

BACKGROUND: Serum neurofilament light chain (sNfL) may be used as a biological marker of disease progression in multiple sclerosis (MS), although longitudinal studies correlating cognitive deficits to sNfL are limited. OBJECTIVE: To longitudinally investigate the relation between cognitive dysfunction, sNfL and MRI brain volume in a relapsing remitting MS patients. METHODS: 18 MS patients (9 males and 9 females, mean age 45 years, mean education 12.6 years) all prescribed with interferon beta 1a (44 mcg 3 times per week), are longitudinally evaluated by means of annual clinical exam with EDSS, neuropsychological evaluation with Brief repeatable battery (BRB) and Delis Kaplan Executive function test (DKEFS), dosage of sNfL (SIMOA) and MRI. RESULTS: Here are reported the results of 1 year follow-up. A significantly higher sNfL in MS compared to healthy controls and higher sNfL in patients with greater cognitive impairment were found. Cognitive Impairment Index, memory, executive function tests correlated with sNfL. Gray matter volume resulted unchanged at 1-year follow-up; a weak correlation between some tests' score and selective cortical brain areas was found. CONCLUSION: Our longitudinal pilot study confirms that sNfL are related to cognitive abilities, confirming data of other authors from retrospective studies

Pagina Web:

https://doi.org/10.1007/s00415-020-09832-1

Id prodotto:

114031

Handle IRIS:

11562/1016125

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Mattioli, Flavia; Bellomi, F; Stampatori, C; Mariotto, S; Ferrari, S; Monaco, S; Mancinelli, C; Capra, R, Longitudinal serum neurofilament light chain (sNfL) concentration relates to cognitive function in multiple sclerosis patients «Journal of Neurology» , vol. 267 , n. 8 , 2020 , pp. 2245-2251

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