Pubblicazioni

Autori:

Zanoni, Mattia; Orlandi, Elisa; Rossetti, Giulia; Turatti, Marco; Calabrese, Massimiliano; Gomez Lira, Macarena; Gajofatto, Alberto

Titolo:

Up-regulated serum miR-128-3p in progressive and relapse-free multiple sclerosis patients

Anno:

2020

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

ACTA NEUROLOGICA SCANDINAVICA

ISSN Rivista:

1600-0404

N° Volume:

142

Numero o Fascicolo:

5

Intervallo pagine:

511-516

Parole chiave:

mir-128-3p; multiple sclerosis; biomarkers; serum; disease activity; disease progression

Breve descrizione dei contenuti:

Background: Circulating microRNAs have emerged as novel multiple sclerosis (MS) biomarkers. Aims: To assess the association between candidate miRs expression in serum samples of patients with MS and the disease course. Methods: Serum levels of ten microRNAs (i.e. miR-199, miR-128-3p, miR-20a-5p, miR-27a-3p, miR-15b-5p, miR-325, miR-92a1-5p, miR-223-5p, miR-22-5p, and miR-23a-5p) were measured in 74 MS cases and 17 non-MS controls consecutively enrolled at Verona University Hospital. The association of microRNAs expression with patients' clinical and MRI features was analyzed. Candidate microRNAs were detected by Real-Time PCR and expressed as ratio of each microRNA level to a normalizer. Results: Serum miR-128-3p levels were higher in progressive than relapsing MS (median ratio 2.86 vs 0.73, p=0.036). In addition, miR-128-3p was up-regulated in patients without relapses after sample collection compared to cases who relapsed (1.64 vs 0.82; p=0.014). miR-128-3p levels and relapse rate were inversely correlated (r= -0.44, p=0.008). Conclusions: Serum levels of mir-128-3p could be related to biological mechanisms underlying MS activity and progression.

Pagina Web:

https://doi.org/10.1111/ane.13288

Id prodotto:

114680

Handle IRIS:

11562/1018643

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Zanoni, Mattia; Orlandi, Elisa; Rossetti, Giulia; Turatti, Marco; Calabrese, Massimiliano; Gomez Lira, Macarena; Gajofatto, Alberto, Up-regulated serum miR-128-3p in progressive and relapse-free multiple sclerosis patients «ACTA NEUROLOGICA SCANDINAVICA» , vol. 142 , n. 5 , 2020 , pp. 511-516

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