Pubblicazioni

Autori:

Fasolo, Adriano; Gallon, Paola; Frigo, Anna Chiara; Birattari, Federica; Monterosso, Cristina; Rapizzi, Emilio; Brighenti, Tommaso; Pedrotti, Emilio; Marro, Costanzo; Viola, Pietro; Ponzin, Diego; Franch, Antonella

Titolo:

Gender medicine in corneal transplantation: influence of sex mismatch on rejection episodes and graft survival in a prospective cohort of patients

Anno:

2021

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

CELL AND TISSUE BANKING

ISSN Rivista:

1389-9333

N° Volume:

22

Numero o Fascicolo:

1

Intervallo pagine:

47-56

Parole chiave:

eye banking; gender mismatch; graft failures; keratoplasty; rejection episodes

Breve descrizione dei contenuti:

To evaluate the effect of donor-to-recipient sex mismatched (male donor corneas to female recipients) on the incidence of rejection episodes and failures up to 1 year after corneal transplantation. Prospective observational cohort study, with donor corneas randomly assigned and surgeons blind to the sex of donor. A unique eye bank retrieved and selected the donor corneas transplanted in 4 ophthalmic units in patients with clinical indication for primary or repeated keratoplasty for optical reasons, perforating or lamellar, either anterior or posterior. Rejection episode defined as any reversible or irreversible endothelial, epithelial or stromal sign, with or without development of corneal edema, and graft failure as a permanently cloudy graft or a regraft for any reason detected or acknowledged during a postoperative ophthalmic visit at any time up to 1 year after surgery were recorded.156 (28.6%) patients resulted donor-to-recipient gender mismatched for H-Y antigen (male donor to female recipient). During the 12 months follow-up, 83 (14.7%, 95% CI 12.0-17.9) grafts showed at least 1 rejection episode and 17 (3.2%, 95% CI 2.0-5.0) failed after immune rejection, among 54 (9.6%, 95% CI 7.4-12.3) grafts failed for all causes. No significant differences between matched and mismatched patients were found for cumulative incidence of both rejection episodes (15.2% and 13.5%) and graft failures following rejection (3.2% and 2.6%), respectively. Multivariable analyses showed that H-Y matching either is not a predictive factor for rejection or graft failure nor seems to influence incidence of failures on respect to patient's risk category. The lack of influence of donor-to-recipient mismatched on the rate of rejections and graft failures resulting from this study do not support the adoption of donor-recipient matching in the allocation of corneas for transplantation.

Pagina Web:

https://doi.org/10.1007/s10561-020-09864-x

Id prodotto:

116165

Handle IRIS:

11562/1025005

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Fasolo, Adriano; Gallon, Paola; Frigo, Anna Chiara; Birattari, Federica; Monterosso, Cristina; Rapizzi, Emilio; Brighenti, Tommaso; Pedrotti, Emilio; Marro, Costanzo; Viola, Pietro; Ponzin, Diego; Franch, Antonella, Gender medicine in corneal transplantation: influence of sex mismatch on rejection episodes and graft survival in a prospective cohort of patients «CELL AND TISSUE BANKING» , vol. 22 , n. 1 , 2021 , pp. 47-56

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo