Pubblicazioni

Autori:

Costa, Enrico; Sterzi, Enrico; Tedeschi, Federico; Casari, Rebecca; Marini, Paola; Lugoboni, Fabio

Titolo:

Can oral formulation increase the risk of lormetazepam abuse?

Anno:

2021

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

INTERNAL AND EMERGENCY MEDICINE

ISSN Rivista:

1828-0447

N° Volume:

16

Numero o Fascicolo:

3

Intervallo pagine:

785-788

Parole chiave:

dependency and tolerance; lormetazepam; oral liquid formulation

Breve descrizione dei contenuti:

The slowness of dripping and the presence of alcohol have been offered/suggested as possible causes for the increased risk of developing dependence to the oral formulation of lormetazepam rather than to other anxiolytic and hypnotic drugs. We hence assessed the time of dripping of the most used benzodiazepines and z-drugs oral solution products under experimental conditions and the different employed excipients through a comparative analysis of the Summaries of Product Characteristics. A wide range of the median overall dispensing time was found across the eight products included in the analysis. Among the products containing LMZ, Minias® ranked in the fourth position, while LMZ Mylan Generics® and Noctamid® in the sixth and third, respectively. Our data suggest that the pace of dripping and the presence of alcohol cannot be considered themselves the cause that triggered the abuse of lormetazepam. More precisely, the quantity of alcohol per bottle has been found negligible at therapeutic doses; however, when these are exceeded, they may have clinical implications for patients. Further studies are needed to assess them. Meanwhile, the public-health problem remains and some improvements should be carried out at different levels, to guarantee the appropriate prescription and use of lormetazepam oral solution.

Pagina Web:

https://doi.org/10.1007/s11739-020-02538-2

Id prodotto:

117091

Handle IRIS:

11562/1027936

ultima modifica:

16 novembre 2022

Citazione bibliografica:

Costa, Enrico; Sterzi, Enrico; Tedeschi, Federico; Casari, Rebecca; Marini, Paola; Lugoboni, Fabio, Can oral formulation increase the risk of lormetazepam abuse? «INTERNAL AND EMERGENCY MEDICINE» , vol. 16 , n. 3 , 2021 , pp. 785-788

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