Pubblicazioni

Autori:

Kiani, Aysha Karim; Falsini, Benedetto; Ziccardi, Lucia; Gusson, Elena; Mangialavori, Domenica; Allegrini, Francesca; Colao, Emma; Bertelli, Matteo

Titolo:

Flavonoid supplements increase neurotrophin activity to modulate inflammation in retinal genetic diseases

Anno:

2020

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

ACTA BIOMEDICA

ISSN Rivista:

2531-6745

N° Volume:

91

Numero o Fascicolo:

13-S

Intervallo pagine:

1-5

Parole chiave:

retinal degenerative disorders; neurotrophin synthesis; flavonoids supplementation; anti-inflammation; anti-oxidant

Breve descrizione dei contenuti:

Retinal degenerative disorders induce loss of photoreceptors associated with inflammation, and negative remodeling and plasticity of neural retina. Retinal degenerative diseases may have genetic and/or environmental causes. Degeneration of retinal pigment epithelium cells initiates a vicious circle increasing the ongoing inflammation in both retina and choroid. Flavonoids are polyphenolic molecules with antioxidant activity and dietary intake, specifically of anthocyanins and flavanols, improves oxidative stress and neuro-inflammation. In vitro and ex vivo studies have also revealed biological effects of flavonoids on retinal protection against oxidative stress and inflammation. In this brief review, the protective role of flavonoids against retinal degeneration and inflammation will be discussed along with their therapeutic potential for the treatment of retinal degenerative diseases.

Pagina Web:

https://doi.org/10.23750/abm.v91i13-S.10683

Id prodotto:

117492

Handle IRIS:

11562/1029615

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Kiani, Aysha Karim; Falsini, Benedetto; Ziccardi, Lucia; Gusson, Elena; Mangialavori, Domenica; Allegrini, Francesca; Colao, Emma; Bertelli, Matteo, Flavonoid supplements increase neurotrophin activity to modulate inflammation in retinal genetic diseases «ACTA BIOMEDICA» , vol. 91 , n. 13-S , 2020 , pp. 1-5

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