Pubblicazioni

Autori:

Monaco, Salvatore; Mariotto, Sara; Ferrari, Sergio

Titolo:

Peripheral neuropathy and central nervous system involvement in cryoglobulinemia

Anno:

2012

Tipologia prodotto:

Contributo in volume (Capitolo o Saggio)

Tipologia ANVUR:

Contributo in volume (Capitolo o Saggio)

Lingua:

Inglese

Formato:

A Stampa

Titolo libro:

HCV Infection and Cryoglobulinemia

Casa editrice:

Springer-Verlag Italia

ISBN:

978-88-470-1704-7

Intervallo pagine:

209-217

Parole chiave:

peripheral neuropathy; sustained virological response; mixed cryoglobulinemia; axonal polyneuropathy; cold agglutinin disease

Breve descrizione dei contenuti:

Cryoglobulins (CG) are immunoglobulins that persist in the serum and have the physical property of precipitating on exposure to cold and resolubilizing when returned to body temperature. Three categories of cryoglobulins are recognized, either essential or secondary to chronic hepatitis C virus (HCV) infection, autoimmune diseases, and lymphoproliferative disorders. Peripheral neuropathy (PN) can occur with all types of CG, although it is usually found in patients with HCV-associated type II CG. PN has different clinical manifestations, ranging from subclinical involvement to symmetrical or asymmetrical sensory, sensorimotor, or motor forms. The mechanisms of nerve involvement are related to small vessel vasculitis, complement-mediated microangiopathy, and HCV-triggered dysimmune responses. The central nervous system (CNS) can be also involved in CG and clinical manifestations are highly variegated. In recent years, the study of HCV-infected individuals has revealed an increased prevalence of cognitive changes and behavioral/neuropsychological symptoms, suggesting a major pathogenic role of HCV, following neuroinvasion and replication. Here, we review the range of neurological complications associated with essential and secondary CG and discuss the available therapeutic options.

Pagina Web:

https://doi.org/10.1007/978-88-470-1705-4_26

Id prodotto:

118017

Handle IRIS:

11562/1031104

ultima modifica:

8 novembre 2022

Citazione bibliografica:

Monaco, Salvatore; Mariotto, Sara; Ferrari, Sergio, Peripheral neuropathy and central nervous system involvement in cryoglobulinemia HCV Infection and Cryoglobulinemia , Springer-Verlag Italia , 2012 , pp. 209-217

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