Pubblicazioni

Adult attention-deficit/hyperactivity disorder symptoms, cognitive dysfunction and quality of life in high-dose use of benzodiazepine and Z-drug  (2021)

Autori:
Federico, Angela; Mantovani, Elisa; Casari, Rebecca; Bertoldi, Anna; Lugoboni, Fabio; Tamburin, Stefano
Titolo:
Adult attention-deficit/hyperactivity disorder symptoms, cognitive dysfunction and quality of life in high-dose use of benzodiazepine and Z-drug
Anno:
2021
Tipologia prodotto:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Lingua:
Inglese
Formato:
A Stampa
Referee:
Nome rivista:
JOURNAL OF NEURAL TRANSMISSION
ISSN Rivista:
0300-9564
N° Volume:
128
Numero o Fascicolo:
7
Intervallo pagine:
1109-1119
Parole chiave:
Attention-deficit/hyperactivity disorder (ADHD); Benzodiazepine (BZD); Cognition; Patient-centered outcomes; Quality of life (QoL); Substance-use disorder (SUD)
Breve descrizione dei contenuti:
High-dose use of benzodiazepines (BZDs) and Z-drugs was found to be associated with adult attention deficit/hyperactivity disorder (ADHD) and multidomain cognitive deficits, but the interplay between these factors and its effect on quality of life (QoL) is unclear. We explored (a) whether cognitive dysfunction differs in high-dose BZD/Z-drug users with and without adult ADHD and (b) the impact of cognitive deficits and adult ADHD on QoL in this substance-use disorder (SUD). From January 2015 to December 2019, we recruited 207 high-dose BZD/Z-drug users seeking treatment. We assessed the presence of adult ADHD with a screening tool, which was validated in SUD patients, and collected demographic, clinical and QoL data from the 76 included patients. A neuropsychological battery explored five cognitive domains. We found that: (a) screening for adult ADHD was frequently positive; (b) Short Form-36 (SF-36), a self-administered QoL questionnaire, was worse than the general population and worse in patients positive (ADHD+) vs. those negative (ADHD-) to ADHD screening tool; (c) executive function was significantly worse in ADHD+than ADHD- patients; (d) some SF-36 dimensions were negatively influenced by executive dysfunction; (e) multivariate analysis showed an interplay between adult ADHD and cognitive dysfunction in worsening QoL. We documented a complex interplay between adult ADHD, cognitive dysfunction and QoL in high-dose BZD/Z-drug users. Assessing adult ADHD, neuropsychological measures and QoL may offer a full scenario of these patients, who are frequently impaired in everyday activities. Future research should explore whether pharmacological treatment might improve cognitive dysfunction and QoL in this SUD.
Pagina Web:
https://doi.org/10.1007/s00702-020-02285-w
Id prodotto:
118578
Handle IRIS:
11562/1032825
ultima modifica:
15 novembre 2022
Citazione bibliografica:
Federico, Angela; Mantovani, Elisa; Casari, Rebecca; Bertoldi, Anna; Lugoboni, Fabio; Tamburin, Stefano, Adult attention-deficit/hyperactivity disorder symptoms, cognitive dysfunction and quality of life in high-dose use of benzodiazepine and Z-drug «JOURNAL OF NEURAL TRANSMISSION» , vol. 128 , n. 72021pp. 1109-1119

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