Pubblicazioni

Autori:

Maniscalco, Giorgia Teresa; Zekeridou, Anastasia; Allegorico, Lia; Ranieri, Angelo; Napolitano, Massimo; Pezzella, Marianna; Gatta, Luigi Della; Manzo, Valentino; Ferrari, Sergio; Mariotto, Sara

Titolo:

GAD65 autoimmunity after treatment with nivolumab: a multifocal presentation

Anno:

2021

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

NEUROLOGICAL SCIENCES

ISSN Rivista:

1590-1874

N° Volume:

42

Numero o Fascicolo:

10

Intervallo pagine:

4289-4291

Parole chiave:

Ataxia; Checkpoint inhibitor; Encephalitis; Epilepsy; GAD65; Stiff person syndrome

Breve descrizione dei contenuti:

Introduction: Neurological disorders are considered rare complications of immune-checkpoint inhibitor. Case description: We report a 63-year-old man with recurrence of melanoma who presented epilepsy, limbic encephalitis, cerebellar ataxia, and stiff person syndrome soon after treatment with nivolumab, an immune-checkpoint inhibitor. On autoimmune screening, serum and CSF GAD65 were detected. Significant response to steroids and intravenous immunoglobulins were observed, but cancer recurred after nivolumab discontinuation in parallel with epileptic seizure and worsening of cognitive impairment and the patient died. Discussion: This case expands the spectrum of GAD65-associated conditions induced by immune-checkpoint inhibitor and underlines treatment complexity when both neurological complications and tumour recurrence occur.

Pagina Web:

https://doi.org/10.1007/s10072-021-05312-0

Id prodotto:

121041

Handle IRIS:

11562/1043337

ultima modifica:

14 novembre 2022

Citazione bibliografica:

Maniscalco, Giorgia Teresa; Zekeridou, Anastasia; Allegorico, Lia; Ranieri, Angelo; Napolitano, Massimo; Pezzella, Marianna; Gatta, Luigi Della; Manzo, Valentino; Ferrari, Sergio; Mariotto, Sara, GAD65 autoimmunity after treatment with nivolumab: a multifocal presentation «NEUROLOGICAL SCIENCES» , vol. 42 , n. 10 , 2021 , pp. 4289-4291

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