Pubblicazioni

Altered vascular endothelium-dependent responsiveness in frail elderly patients recovering from {COVID}-19 pneumonia: preliminary evidence  (2021)

Autori:
Paneroni, Mara; Pasini, Evasio; Vitacca, Michele; Scalvini, Simonetta; Comini, Laura; Pedrinolla, Anna; Venturelli, Massimo
Titolo:
Altered vascular endothelium-dependent responsiveness in frail elderly patients recovering from {COVID}-19 pneumonia: preliminary evidence
Anno:
2021
Tipologia prodotto:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Lingua:
Inglese
Formato:
Elettronico
Referee:
Nome rivista:
JOURNAL OF CLINICAL MEDICINE
ISSN Rivista:
2077-0383
N° Volume:
10
Numero o Fascicolo:
2558
Intervallo pagine:
1-9
Parole chiave:
COVID-19; vascular function; inflammation; nitric oxide.
Breve descrizione dei contenuti:
We evaluated vascular dysfunction with the single passive leg movement test (sPLM) in 22 frail elderly patients at 84 + 31 days after hospitalization for COVID-19 pneumonia, compared to 22 age-, sex- and comorbidity-matched controls (CTRL). At rest, all COVID-19 patients were in stable clinical condition without severe comorbidities. Patients (aged 72 ± 6 years, 73% male) had moderate disability (Barthel index score 77 ± 26), hypoxemia and normocapnia at arterial blood gas analysis and mild pulmonary restriction at spirometry. Values of circulating markers of inflammation (C-reactive protein: CRP; erythrocyte sedimentation rate: ESR) and coagulation (D-dimer) were: 27.13 ± 37.52 mg/dL, 64.24 ± 32.37 mm/1 h and 1043 ± 729 ng/mL, respectively. At rest, femoral artery diameter was similar in COVID-19 and CTRL (p = 0.16). On the contrary, COVID-19 infection deeply impacted blood velocity (p = 0.001) and femoral blood flow (p < 0.0001). After sPLM, peak femoral blood flow was dramatically reduced in COVID-19 compared to CTRL (p = 0.001), as was blood flow ∆peak (p = 0.05) and the area under the curve (p < 0.0001). This altered vascular responsiveness could be one of the unknown components of long COVID-19 syndrome leading to fatigue, changes in muscle metabolism and fibers’ composition, exercise intolerance and increased cardiovascular risk. Impact of specific treatments, such as exercise training, dietary supplements or drugs, should be evaluated.
Pagina Web:
https://doi.org/10.3390/jcm10122558
Id prodotto:
121712
Handle IRIS:
11562/1045583
ultima modifica:
12 novembre 2022
Citazione bibliografica:
Paneroni, Mara; Pasini, Evasio; Vitacca, Michele; Scalvini, Simonetta; Comini, Laura; Pedrinolla, Anna; Venturelli, Massimo, Altered vascular endothelium-dependent responsiveness in frail elderly patients recovering from {COVID}-19 pneumonia: preliminary evidence «JOURNAL OF CLINICAL MEDICINE» , vol. 10 , n. 25582021pp. 1-9

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo IRIS

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