Pubblicazioni

Autori:

Mariotto, Sara; Carta, Sara; Dinoto, Alessandro; Lippi, Giuseppe; Salvagno, Gian Luca; Masin, Laura; Alberti, Daniela; Marignier, Romain; Ferrari, Sergio

Titolo:

Is there a correlation between MOGAD and SARS-CoV-2 infection?

Anno:

2022

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

European Journal Of Neurology

ISSN Rivista:

1351-5101

N° Volume:

29

Numero o Fascicolo:

6

Intervallo pagine:

1855-1858

Parole chiave:

COVID-19; MOG; SARS-CoV-2; myelitis; optic neuritis

Breve descrizione dei contenuti:

Background: MOG-Abs distinguish a group of inflammatory disorders which can be preceded by specific or non-specific infections. Few single cases have been reported in association with SARS-CoV-2 infection, but a specific study on the correlation between COVID-19 and MOG-associated disorder (MOGAD) has not been performed, yet. Aim of this study is to determine the impact of the pandemic on this condition. Methods: We analysed SARS-CoV-2 serology in newly diagnosed MOG-Abs patients (August 1st 2020-May 31st 2021). MOG-Ab seronegative age and time-matched subjects were used as controls. SARS-CoV-2 IgG were analysed using an anti-SARS-CoV-2 FDA-approved ELISA assay (Euroimmun, Luebeck, Germany) and confirmed with a trimeric anti-SARS-CoV-2 S1/S2 IgG immunochemiluminescent test (DiaSorin), concomitantly assaying anti-Receptor Binding Domain (RBD) of spike protein (Beckman) IgG and anti-RBD total Ig (Roche). We then compared the number of cases referred in the last 3 years. Results: SARS-CoV-2 IgG were more common (12/30, 40%) in MOGAD than in controls (6/30, 20%), although the difference was not significant (p=0.16; OR=2.67, 95% CI 0.85-9.17). The most common clinical presentations of MOGAD SARS-CoV-2 seropositive cases included optic neuritis (n=6) and myelitis (n=3). The number of diagnosed cases increased in the last 3 years, in particular, when including cases referred before the COVID-19 pandemic, in the initial phase of the first wave and in the late phase of the second wave (n=9, rate 10.6% in 2019; n=13, rate 12.3% in 2020; n=and 15, rate 14.7% in 2021). Conclusion: Our findings provide preliminary data on SARS-CoV-2 as a potential trigger of MOGAD.

Pagina Web:

https://doi.org/10.1111/ene.15304

Id prodotto:

125110

Handle IRIS:

11562/1058663

ultima modifica:

29 novembre 2022

Citazione bibliografica:

Mariotto, Sara; Carta, Sara; Dinoto, Alessandro; Lippi, Giuseppe; Salvagno, Gian Luca; Masin, Laura; Alberti, Daniela; Marignier, Romain; Ferrari, Sergio, Is there a correlation between MOGAD and SARS-CoV-2 infection? «European Journal Of Neurology» , vol. 29 , n. 6 , 2022 , pp. 1855-1858

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