- Autori:
-
Stefano, Piermarocchi; Sandro, Saviano; Vincenzo, Parisi; Massimiliano, Tedeschi; Giacomo, Panozzo; Giuseppe, Scarpa; Giorgio, Boschi; Giuseppe, Lo Giudice; Carmis Study Group, The; Sartore, Mauro; Monterosso, Gianluca; Fregona, Iva; Cavarzeran, Fabiano; Battaglia Parodi, Maurizio; Di Stefano, Giuseppe; Varano, Monica; Capaldo, Nicoletta; Pignatto, Silvia; Gusson, Elena; Parolini, Barbara; Del Sal, Carla; Virgili, Gianni
- Titolo:
-
Carotenoids in Age-related Maculopathy Italian Study (CARMIS): two-year results of a randomized study
- Anno:
-
2012
- Tipologia prodotto:
-
Articolo in Rivista
- Tipologia ANVUR:
- Articolo su rivista
- Lingua:
-
Inglese
- Formato:
-
A Stampa
- Referee:
-
Sì
- Nome rivista:
- European Journal of Ophthalmology
- ISSN Rivista:
- 1120-6721
- N° Volume:
-
22
- Numero o Fascicolo:
-
2
- Intervallo pagine:
-
216-225
- Parole chiave:
-
Age-related macular degeneration; Carotenoids; Lutein; Macular pigment; Zeaxanthin
- Breve descrizione dei contenuti:
- PURPOSE. The high concentration of carotenoids in the macula, plus evidence linking oxidative stress to age-related macular degeneration (AMD) and carotenoids to antioxidation, generated the hypothesis that higher antioxidant intakes can prevent AMD. The aim of this study was to determine whether nutritional supplementation with a targeted nutritional supplement improves visual acuity and visual function in AMD.METHODS. In this multicenter, prospective open-label randomized study, 145 patients were randomly assigned to 2 different treatment groups. Interventions were lutein (10 mg), zeaxanthin (1 mg), astaxanthin (4 mg; AZYR SIFI, Catania, Italy), and antioxidants/vitamins supplementation formula or no dietary supplementation for 2 years. Primary outcome was mean changes in visual acuity (VA) at 12 and 24 months. Other measures included contrast sensitivity (CS) and National Eye Institute visual function questionnaire (NEI VFQ-25) scores at 12 and 24 months.RESULTS. Patients in the treated group showed stabilization of VA with significantly (p=0.003) better VA scores (81.4 +/- 7.2) compared to the nontreated group (76.8 +/- 8.9) at 24-month follow-up. An improvement in CS (p=0.001) and final mean NEI VFQ-25 composite scores at 12 and 24 months higher in treated group compared to nontreated group were also shown (p<0.001).CONCLUSIONS. Patients treated with lutein/zeaxanthin and astaxanthin together with other nutrients were more likely to report clinically meaningful stabilization/improvements in VA, CS, and visual function through 24 months compared with nontreated subjects. Further studies are needed with more patients and for longer periods of time.
- Pagina Web:
-
https://doi.org/10.5301/ejo.5000069
- Id prodotto:
-
128105
- Handle IRIS:
-
11562/1072349
- ultima modifica:
-
23 febbraio 2023
- Citazione bibliografica:
-
Stefano, Piermarocchi; Sandro, Saviano; Vincenzo, Parisi; Massimiliano, Tedeschi; Giacomo, Panozzo; Giuseppe, Scarpa; Giorgio, Boschi; Giuseppe, Lo Giudice; Carmis Study Group, The; Sartore, Mauro; Monterosso, Gianluca; Fregona, Iva; Cavarzeran, Fabiano; Battaglia Parodi, Maurizio; Di Stefano, Giuseppe; Varano, Monica; Capaldo, Nicoletta; Pignatto, Silvia; Gusson, Elena; Parolini, Barbara; Del Sal, Carla; Virgili, Gianni,
Carotenoids in Age-related Maculopathy Italian Study (CARMIS): two-year results of a randomized study
«European Journal of Ophthalmology»
, vol.
22
, n.
2
,
2012
,
pp. 216-225
Consulta la scheda completa presente nel
repository istituzionale della Ricerca di Ateneo