Pubblicazioni

Autori:

Stefano, Piermarocchi; Sandro, Saviano; Vincenzo, Parisi; Massimiliano, Tedeschi; Giacomo, Panozzo; Giuseppe, Scarpa; Giorgio, Boschi; Giuseppe, Lo Giudice; Carmis Study Group, The; Sartore, Mauro; Monterosso, Gianluca; Fregona, Iva; Cavarzeran, Fabiano; Battaglia Parodi, Maurizio; Di Stefano, Giuseppe; Varano, Monica; Capaldo, Nicoletta; Pignatto, Silvia; Gusson, Elena; Parolini, Barbara; Del Sal, Carla; Virgili, Gianni

Titolo:

Carotenoids in Age-related Maculopathy Italian Study (CARMIS): two-year results of a randomized study

Anno:

2012

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

European Journal of Ophthalmology

ISSN Rivista:

1120-6721

N° Volume:

22

Numero o Fascicolo:

2

Intervallo pagine:

216-225

Parole chiave:

Age-related macular degeneration; Carotenoids; Lutein; Macular pigment; Zeaxanthin

Breve descrizione dei contenuti:

PURPOSE. The high concentration of carotenoids in the macula, plus evidence linking oxidative stress to age-related macular degeneration (AMD) and carotenoids to antioxidation, generated the hypothesis that higher antioxidant intakes can prevent AMD. The aim of this study was to determine whether nutritional supplementation with a targeted nutritional supplement improves visual acuity and visual function in AMD.METHODS. In this multicenter, prospective open-label randomized study, 145 patients were randomly assigned to 2 different treatment groups. Interventions were lutein (10 mg), zeaxanthin (1 mg), astaxanthin (4 mg; AZYR SIFI, Catania, Italy), and antioxidants/vitamins supplementation formula or no dietary supplementation for 2 years. Primary outcome was mean changes in visual acuity (VA) at 12 and 24 months. Other measures included contrast sensitivity (CS) and National Eye Institute visual function questionnaire (NEI VFQ-25) scores at 12 and 24 months.RESULTS. Patients in the treated group showed stabilization of VA with significantly (p=0.003) better VA scores (81.4 +/- 7.2) compared to the nontreated group (76.8 +/- 8.9) at 24-month follow-up. An improvement in CS (p=0.001) and final mean NEI VFQ-25 composite scores at 12 and 24 months higher in treated group compared to nontreated group were also shown (p<0.001).CONCLUSIONS. Patients treated with lutein/zeaxanthin and astaxanthin together with other nutrients were more likely to report clinically meaningful stabilization/improvements in VA, CS, and visual function through 24 months compared with nontreated subjects. Further studies are needed with more patients and for longer periods of time.

Pagina Web:

https://doi.org/10.5301/ejo.5000069

Id prodotto:

128105

Handle IRIS:

11562/1072349

ultima modifica:

23 febbraio 2023

Citazione bibliografica:

Stefano, Piermarocchi; Sandro, Saviano; Vincenzo, Parisi; Massimiliano, Tedeschi; Giacomo, Panozzo; Giuseppe, Scarpa; Giorgio, Boschi; Giuseppe, Lo Giudice; Carmis Study Group, The; Sartore, Mauro; Monterosso, Gianluca; Fregona, Iva; Cavarzeran, Fabiano; Battaglia Parodi, Maurizio; Di Stefano, Giuseppe; Varano, Monica; Capaldo, Nicoletta; Pignatto, Silvia; Gusson, Elena; Parolini, Barbara; Del Sal, Carla; Virgili, Gianni, Carotenoids in Age-related Maculopathy Italian Study (CARMIS): two-year results of a randomized study «European Journal of Ophthalmology» , vol. 22 , n. 2 , 2012 , pp. 216-225

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo