Pubblicazioni

Autori:

Pedrinolla, Anna; Berg, Ole Kristian; Tøien, Tiril; Wang, Eivind

Titolo:

Aging increases metabolic capacity and reduces work efficiency during handgrip exercise in males

Anno:

2023

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

JOURNAL OF APPLIED PHYSIOLOGY

ISSN Rivista:

8750-7587

N° Volume:

134

Numero o Fascicolo:

5

Editore:

American Physiological Society:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7180, EMAIL: subscrip@the-aps.org, INTERNET: http://www.the-aps.org, Fax: (301)571-8313

Intervallo pagine:

1154-1164

Parole chiave:

V̇O2peak; forearm; muscle diffusion; vascular conductance; vascular function

Breve descrizione dei contenuti:

Maximal oxygen uptake and exercise performance typically decline with age. However, there are indications of preserved vascular function and blood flow regulation during arm exercise. Yet, it is unknown if this potential physiological preservation with age is mirrored in peripheral metabolic capacity and V̇O2/watt ratio. Thus, to investigate the effects of aging in the arms, we measured metabolic and vascular responses to 6-minute bouts of dynamic handgrip exercise at 40% and 80% of maximal work rate (WRmax) in eleven young (26±2yr) and twelve old (80±6yr) males, applying Doppler-ultrasound combined with blood samples from a deep forearm vein. At baseline, old had a larger arterial diameter compared to young (p<0.001). During exercise, the two groups reached the same WRmax. V̇O2, blood flow, and oxygen supply were higher (40%WRmax; 80%WRmax, all p<0.01), and arterio-venous oxygen-difference lower (80%WRmax, p<0.02), in old compared to young. Old also had a higher oxygen-excess at 80%WRmax (p<0.01) than young, while no difference in muscle diffusion or oxygen-extraction was detected. Only young exhibited an increase in intensity-induced arterial dilation (p<0.05), and they had a lower mean arterial pressure than old at 80%WRmax (p<0.001). V̇O2/watt (40%WRmax; 80%WRmax) was reduced in old compared to young (both p<0.05). In conclusion, in old and young males with a similar handgrip WRmax, old had a higher V̇O2 during 80%WRmax intensity, achieved by an increased blood flow. This may be a result of the available cardiac output reserve, compensating for reduced work efficiency and attenuated vascular response observed in old.

Note:

A. Pedrinolla and O. K. Berg contributed equally to this work.

Pagina Web:

https://doi.org/10.1152/japplphysiol.00411.2022

Id prodotto:

133380

Handle IRIS:

11562/1092308

ultima modifica:

9 giugno 2023

Citazione bibliografica:

Pedrinolla, Anna; Berg, Ole Kristian; Tøien, Tiril; Wang, Eivind, Aging increases metabolic capacity and reduces work efficiency during handgrip exercise in males «JOURNAL OF APPLIED PHYSIOLOGY» , vol. 134 , n. 5 , 2023 , pp. 1154-1164

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