Pubblicazioni

Autori:

Campetella, Lucia; Papi, Claudia; Spagni, Gregorio; Sabatelli, Eleonora; Mariotto, Sara; Gastaldi, Matteo; Masi, Gianvito; Carta, Sara; Ahmad, Lara; Rossi, Francesca; Maniscalco, Giorgia Teresa; De Luca, Giovanna; Iorio, Raffaele

Titolo:

A score that predicts aquaporin-4-IgG positivity in patients with longitudinally extensive transverse myelitis

Anno:

2023

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

European Journal Of Neurology

ISSN Rivista:

1351-5101

N° Volume:

30

Numero o Fascicolo:

8

Intervallo pagine:

2534-2538

Parole chiave:

Aquaporin 4; Myelitis; Myelitis, Transverse; Neuromyelitis Optica

Breve descrizione dei contenuti:

Background: Longitudinally extensive transverse myelitis (LETM) associated with aquaporin-4 autoantibodies (AQP4-IgG) can cause severe disability. Early diagnosis and prompt treatment are critical to prevent relapses. We describe a novel score based on clinical and neuroimaging characteristics that predicts AQP4-IgG positivity in patients with LETM. Methods: Patients were enrolled both retrospectively and prospectively from multiple Italian centers. Clinical and neuroimaging characteristics of AQP4-IgG positive and negative patients were compared through univariate and multivariate analysis. Results: Sixty-six patients were included. Twenty-seven (41%) were AQP4-IgG positive and median age at onset was 45.5 years old (range 19-81, interquartile range 24). Female sex (odds ratio [OR] 17.9; 95% confidence interval [CI] 2.6-381.9; p=0.014), tonic spasms (OR 45.6; CI 3.1-2197; p=0.017) and lesion hypointensity on T1-weighted images (OR 52.9; CI 6.8-1375; p=0.002) were independently associated with AQP4-IgG positivity. The Aquaporin-4-IgG positivity in Myelitis (AIM) score predicted AQP4-IgG positivity with 85% sensitivity and 95% specificity. Positive and negative likelihood ratio were 16.6 and 0.2 respectively. The inter-rater and intra-rater agreement in the score application were both excellent. Conclusions: The AIM score predicts AQP4-IgG positivity with good sensitivity and specificity in patients with a first episode of LETM. The score may assist clinicians in early diagnosis and treatment of AQP4-IgG positive LETM.

Pagina Web:

https://doi.org/10.1111/ene.15863

Id prodotto:

134379

Handle IRIS:

11562/1096570

ultima modifica:

12 luglio 2023

Citazione bibliografica:

Campetella, Lucia; Papi, Claudia; Spagni, Gregorio; Sabatelli, Eleonora; Mariotto, Sara; Gastaldi, Matteo; Masi, Gianvito; Carta, Sara; Ahmad, Lara; Rossi, Francesca; Maniscalco, Giorgia Teresa; De Luca, Giovanna; Iorio, Raffaele, A score that predicts aquaporin-4-IgG positivity in patients with longitudinally extensive transverse myelitis «European Journal Of Neurology» , vol. 30 , n. 8 , 2023 , pp. 2534-2538

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