Pubblicazioni

Autori:

Dinoto, Alessandro; Trentinaglia, Milena; Carta, Sara; Mantovani, Elisa; Ferrari, Sergio; Tamburin, Stefano; Tinazzi, Michele; Mariotto, Sara

Titolo:

Autoimmune movement disorders complicating treatment with immune checkpoint inhibitors

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

MOVEMENT DISORDERS CLINICAL PRACTICE

ISSN Rivista:

2330-1619

N° Volume:

11

Numero o Fascicolo:

5

Intervallo pagine:

543-549

Parole chiave:

autoimmune movement disorders; immune checkpoint inhibitors; immune-related adverse events; paraneoplastic neurological syndrome

Breve descrizione dei contenuti:

Background: Immune checkpoint inhibitors (ICI) may trigger autoimmune neurological conditions, including movement disorders (MD). Objectives: The aim of this study was to characterize MDs occurring as immune-related adverse events (irAEs) of ICIs. Methods: A systematic literature review of case reports/series of MDs as irAEs of ICIs was performed. Results: Of 5682 eligible papers, 26 articles with 28 patients were included. MDs occur as a rare complication of cancer immunotherapy with heterogeneous clinical presentations and in most cases in association with other irAEs. Inflammatory basal ganglia T2/fluid attenuated inversion recovery abnormalities are rarely observed, but brain imaging is frequently unrevealing. Cerebrospinal fluid findings are frequently suggestive of inflammation. Half of cases are associated with a wide range of autoantibodies. Steroids and ICI withdrawal usually lead to improvement, even though some patients experienced relapses or a severe clinical course. Conclusion: MDs are a rare complication of ICIs that should be promptly recognized to offer patients a correct diagnosis and treatment.

Pagina Web:

https://doi.org/10.1002/mdc3.14003

Id prodotto:

138286

Handle IRIS:

11562/1121087

ultima modifica:

24 maggio 2024

Citazione bibliografica:

Dinoto, Alessandro; Trentinaglia, Milena; Carta, Sara; Mantovani, Elisa; Ferrari, Sergio; Tamburin, Stefano; Tinazzi, Michele; Mariotto, Sara, Autoimmune movement disorders complicating treatment with immune checkpoint inhibitors «MOVEMENT DISORDERS CLINICAL PRACTICE» , vol. 11 , n. 5 , 2024 , pp. 543-549

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