Pubblicazioni

Autori:

Ingason, A.; Giegling, I.; Cichon, S.; Hansen, T.; Rasmussen, H. B.; Nielsen, J.; Jurgens, G.; Muglia, P.; Hartmann, A. M.; Strengman, E.; Vasilescu, C.; Muhleisen, T. W.; Djurovic, S.; Melle, I.; Lerer, B.; Moller, H. J.; Francks, C.; Pietilainen, O. P.; Lonnqvist, J.; Suvisaari, J.; Tuulio Henriksson, A.; Walshe, M.; Vassos, E.; Forti, M. D.; Murray, R.; Bonetto, Chiara; Tosato, Sarah; Cantor, R. M.; Rietschel, M.; Craddock, N.; Owen, M. J.; Peltonen, L.; Andreassen, O. A.; Nothen, M. M.; Clair, D. S.; Ophoff, R. A.; O'Donovan, M. C.; Collier, D. A.; Werge, T.; Rujescu, D.

Titolo:

A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia

Anno:

2010

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

No

Nome rivista:

Human Molecular Genetics

ISSN Rivista:

0964-6906

N° Volume:

19

Numero o Fascicolo:

7

Intervallo pagine:

1379-1386

Parole chiave:

genome-wide association; joubert syndrome; susceptibility locus; common variants; chromosome 6Q23; mutations cause; follow-up; gene; risk; disorder

Breve descrizione dei contenuti:

The Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that were initially identified by linkage followed by linkage disequilibrium mapping, and subsequent replication of the association in an independent sample. Here, we present results of a replication study of AHI1 locus markers, previously implicated in schizophrenia, in a large European sample (in total 3907 affected and 7429 controls). Furthermore, we perform a meta-analysis of the implicated markers in 4496 affected and 18 920 controls. Both the replication study of new samples and the meta-analysis show evidence for significant overrepresentation of all tested alleles in patients compared with controls (meta-analysis; P = 8.2 x 10(-5)-1.7 x 10(-3), common OR = 1.09-1.11). The region contains two genes, AHI1and C6orf217, and both genes-as well as the neighbouring phosphodiesterase 7B (PDE7B)-may be considered candidates for involvement in the genetic aetiology of schizophrenia.

Id prodotto:

53917

Handle IRIS:

11562/340006

depositato il:

6 aprile 2010

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Ingason, A.; Giegling, I.; Cichon, S.; Hansen, T.; Rasmussen, H. B.; Nielsen, J.; Jurgens, G.; Muglia, P.; Hartmann, A. M.; Strengman, E.; Vasilescu, C.; Muhleisen, T. W.; Djurovic, S.; Melle, I.; Lerer, B.; Moller, H. J.; Francks, C.; Pietilainen, O. P.; Lonnqvist, J.; Suvisaari, J.; Tuulio Henriksson, A.; Walshe, M.; Vassos, E.; Forti, M. D.; Murray, R.; Bonetto, Chiara; Tosato, Sarah; Cantor, R. M.; Rietschel, M.; Craddock, N.; Owen, M. J.; Peltonen, L.; Andreassen, O. A.; Nothen, M. M.; Clair, D. S.; Ophoff, R. A.; O'Donovan, M. C.; Collier, D. A.; Werge, T.; Rujescu, D., A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia «Human Molecular Genetics» , vol. 19 , n. 7 , 2010 , pp. 1379-1386

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