Pubblicazioni

Autori:

Dusi, Nicola; Perlini, Cinzia; Bellani, Marcella; Brambilla, P.

Titolo:

Alla ricerca di endofenotipi psicosociali nella schizofrenia: Il ruolo innovativo del brain imaging. [Searching for psychosocial endophenotypes in schizophrenia: the innovative role of brain imaging.]

Anno:

2012

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Italiano

Formato:

A Stampa

Referee:

Sì

Nome rivista:

RIVISTA DI PSICHIATRIA

ISSN Rivista:

2038-2502

N° Volume:

47

Numero o Fascicolo:

2

Intervallo pagine:

76-88

Parole chiave:

schizophrenia; psychosocial endophenotypes; brain imaging

Breve descrizione dei contenuti:

Schizophrenia is a disease with heterogeneous features and often a disabling longitudinal outcome. In order to achieve a better understanding of the disease, a detailed characterization and definition of symptomatology, social functioning and cognitive performance of patients is required. Imaging techniques may allow to identify measurable markers of different subgroups of patients, who share common clinical course and, probably, a similar hereditary pathway. The review offers a description of cross-sectional, predictive and longitudinal studies on the relationship between biological, clinical and psychosocial features of patients with schizophrenia. Patients with a more severe and disabling course of illness present larger ventricles, smaller prefrontal, temporal and occipital cortices and smaller subcortical regions such as basal ganglia, the thalamus and limbic areas. These alterations are predictive of a worse prognosis, as observed in predictive and longitudinal studies, both on chronic and first episode patients. The detection of more homogenous groups of patients with schizophrenia will help neurobiological research progress in this field. Furthermore, patients with similar clinical and biological features could undergo more tailored therapeutic and rehabilitative strategies.

Pagina Web:

https://doi.org/10.1708/1069.11712

Id prodotto:

69201

Handle IRIS:

11562/424738

depositato il:

5 luglio 2012

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Dusi, Nicola; Perlini, Cinzia; Bellani, Marcella; Brambilla, P., Alla ricerca di endofenotipi psicosociali nella schizofrenia: Il ruolo innovativo del brain imaging. [Searching for psychosocial endophenotypes in schizophrenia: the innovative role of brain imaging.] «RIVISTA DI PSICHIATRIA» , vol. 47 , n. 2 , 2012 , pp. 76-88

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo