Pubblicazioni

Autori:

Diwadkar, Vaibhav A; Bellani, Marcella; Ahmed, Rizwan; Dusi, Nicola; Rambaldelli, Gianluca; Perlini, Cinzia; Marinelli, Veronica; Ramaseshan, Karthik; Ruggeri, Mirella; Bambilla, Paolo

Titolo:

Chronological age and its impact on associative learning proficiency and brain structure in middle adulthood

Anno:

2016

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Behavioural Brain Research

ISSN Rivista:

0166-4328

N° Volume:

297

Intervallo pagine:

329-337

Parole chiave:

aging; associative learning; brain structure; hippocampus; life span changes; voxel based morphometry

Breve descrizione dei contenuti:

INTRODUCTION: The rate of biological change in middle-adulthood is relatively under-studied. Here, we used behavioral testing in conjunction with structural magnetic resonance imaging to examine the effects of chronological age on associative learning proficiency and on brain regions that previous functional MRI studies have closely related to the domain of associative learning.METHODS: Participants (n=66) completed a previously established associative learning paradigm, and consented to be scanned using structural magnetic resonance imaging. Age-related effects were investigated both across sub-groups in the sample (younger vs. older) and across the entire sample (using regression approaches).RESULTS: Chronological age had substantial effects on learning proficiency (independent of IQ and Education Level), with older adults showing a decrement compared to younger adults. In addition, decreases in estimated gray matter volume were observed in multiple brain regions including the hippocampus and the dorsal prefrontal cortex, both of which are strongly implicated in associative learning.CONCLUSION: The results suggest that middle adulthood may be a more dynamic period of life-span change than previously believed. The conjunctive application of narrowly focused tasks, with conjointly acquired structural MRI data may allow us to enrich the search for, and the interpretation of, age-related changes in cross-sectional samples.

Pagina Web:

http://dx.doi.org/10.1016/j.bbr.2015.10.016

Id prodotto:

88851

Handle IRIS:

11562/929284

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Diwadkar, Vaibhav A; Bellani, Marcella; Ahmed, Rizwan; Dusi, Nicola; Rambaldelli, Gianluca; Perlini, Cinzia; Marinelli, Veronica; Ramaseshan, Karthik; Ruggeri, Mirella; Bambilla, Paolo, Chronological age and its impact on associative learning proficiency and brain structure in middle adulthood «Behavioural Brain Research» , vol. 297 , 2016 , pp. 329-337

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