Pubblicazioni

Autori:

Dusi, Nicola; Bellani, Marcella; Perlini, Cinzia; Squarcina, L.; Marinelli, Veronica; Finos, L.; Altamura, C. A.; Ruggeri, Mirella; Brambilla, Paolo

Titolo:

Progressive disability and prefrontal shrinkage in schizophrenia patients with poor outcome: A 3-year longitudinal study

Anno:

2017

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Schizophrenia Research

ISSN Rivista:

0920-9964

N° Volume:

179

Intervallo pagine:

104-111

Parole chiave:

disability; dorsolateral prefrontal cortex; follow-up; magnetic resonance; orbitofrontal cortex; prefrontal cortex; psychosis

Breve descrizione dei contenuti:

INTRODUCTION: Schizophrenia is a severe disabling disorder with heterogeneous illness courses. In this longitudinal study we characterized schizophrenia patients with poor and good outcome (POS, GOS), using functional and imaging metrics. Patients were defined in accordance to Keefe's criteria (i.e. Kraepelinian and non-Kraepelinian patients). METHODS: 35 POS patients, 35 GOS patients and 76 healthy controls (H) underwent clinical, functioning and magnetic resonance imaging (MRI) assessments twice over three years of follow-up. Information on psychopathology, treatment, disability (using the World Health Organization Disability Assessment Scale II, WHO-DAS-2) and prefrontal morphology was collected. Dorsolateral prefrontal cortex (DLPFC) and orbitofrontal cortex (OFC) were manually traced. RESULTS: At baseline, subjects with POS showed significantly decreased right dorsolateral prefrontal cortex (DLPFC) white matter volumes (WM) compared to healthy controls and GOS patients (POS VS HC, p<0.001; POS vs GOS, p=0.03), with shrinkage of left DLPFC WM volumes at follow up (t=2.66, p=0.01). Also, POS patients had higher disability in respect to GOS subjects both at baseline and after 3years at the WHO-DAS-2 (p<0.05). DISCUSSION: Our study supports the hypothesis that POS is characterized by progressive deficits in brain structure and in "real-life" functioning. These are particularly notable in the DLPFC.

Pagina Web:

https://dx.doi.org/10.1016/j.schres.2016.09.013

Id prodotto:

95438

Handle IRIS:

11562/956014

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Dusi, Nicola; Bellani, Marcella; Perlini, Cinzia; Squarcina, L.; Marinelli, Veronica; Finos, L.; Altamura, C. A.; Ruggeri, Mirella; Brambilla, Paolo, Progressive disability and prefrontal shrinkage in schizophrenia patients with poor outcome: A 3-year longitudinal study «Schizophrenia Research» , vol. 179 , 2017 , pp. 104-111

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo