Pubblicazioni

Autori:

Gajofatto, Alberto; Turatti, Marco; Benedetti, Mariadonata

Titolo:

Primary progressive multiple sclerosis: current therapeutic strategies and future perspectives

Anno:

2017

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

EXPERT REVIEW OF NEUROTHERAPEUTICS

ISSN Rivista:

1473-7175

N° Volume:

17

Numero o Fascicolo:

4

Intervallo pagine:

393-406

Parole chiave:

disease-modifying therapy; immunomodulatory drugs; immunosuppressive drugs; multiple sclerosis; ocrelizumab; primary progressive; treatment

Breve descrizione dei contenuti:

Multiple sclerosis (MS) is a chronic inflammatory condition of the central nervous system with heterogeneous features. Primary progressive (PP) MS is a rare disease subtype characterized by continuous disability worsening from onset. No disease-modifying therapy is currently approved for PP MS due to the negative or inconsistent results of clinical trials conducted on a wide range of interventions, which are reviewed in the present paper. Areas covered: The features and results of randomized trials of disease-modifying treatments for PP MS are discussed, including immunosuppressants, immunomodulators, monoclonal antibodies, and putative neuroprotective agents. Expert Commentary: The recent encouraging results of the ocrelizumab trial in PP MS, the first to reach the primary disability endpoint, indicate B cells as a promising therapeutic target to prevent disease progression. Other emerging treatment strategies include cell metabolism modulation and inflammatory pathways inhibition, which are being investigated in several ongoing phase II and III placebo-controlled trials. Future PP MS trials will need to systematically include efficacy endpoints other than physical disability alone, such as cognition, quality of life, advanced MRI measures and molecular biomarkers.

Pagina Web:

http://dx.doi.org/10.1080/14737175.2017.1257385

Id prodotto:

96372

Handle IRIS:

11562/959202

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Gajofatto, Alberto; Turatti, Marco; Benedetti, Mariadonata, Primary progressive multiple sclerosis: current therapeutic strategies and future perspectives «EXPERT REVIEW OF NEUROTHERAPEUTICS» , vol. 17 , n. 4 , 2017 , pp. 393-406

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo