Pubblicazioni

Autori:

Cagnin, Annachiara; Mariotto, Sara; Fiorini, Michele; Gaule, Marina; Bonetto, Nicola; Tagliapietra, Matteo; Buratti, Emanuele; Zanusso, Gianluigi; Ferrari, Sergio; Monaco, Salvatore

Titolo:

Microglial and Neuronal TDP-43 Pathology in Anti-IgLON5-Related Tauopathy

Anno:

2017

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

JOURNAL OF ALZHEIMER'S DISEASE

ISSN Rivista:

1387-2877

N° Volume:

59

Numero o Fascicolo:

1

Intervallo pagine:

13-20

Parole chiave:

IgLON5; TDP-43 pathology; microglia; non-cell autonomous neurodegeneration; tauopathy

Breve descrizione dei contenuti:

A novel neuronal tauopathy, mainly confined to hypothalamus and brainstem tegmentum, has recently been reported in patients with autoantibodies to the neuronal cell-adhesion molecule IgLON5. We describe a patient with anti-IgLON5 syndrome, who presented with dysautonomia and sleep disorder, followed by subacute dementia. Postmortem brain examination disclosed neuronal tau pathology prevailing in the hippocampus, amygdala, and locus coeruleus, in addition to microglial/neuronal TDP-43 pathology, with overexpression of aberrantly phosphorylated forms and neurotoxic truncated fragments, in basal ganglia, nucleus basalis, thalamus, and midbrain. These findings suggest that neurodegeneration in anti-IgLON5 syndrome might also occur via a microglia-triggered non-cell autonomous pathway.

Pagina Web:

https://doi.org/10.3233/JAD-170189

Id prodotto:

98524

Handle IRIS:

11562/966905

ultima modifica:

26 novembre 2022

Citazione bibliografica:

Cagnin, Annachiara; Mariotto, Sara; Fiorini, Michele; Gaule, Marina; Bonetto, Nicola; Tagliapietra, Matteo; Buratti, Emanuele; Zanusso, Gianluigi; Ferrari, Sergio; Monaco, Salvatore, Microglial and Neuronal TDP-43 Pathology in Anti-IgLON5-Related Tauopathy «JOURNAL OF ALZHEIMER'S DISEASE» , vol. 59 , n. 1 , 2017 , pp. 13-20

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo