Pubblicazioni

Autori:

Bo, Marco; Niegowska, Magdalena; Arru, Giannina; Sechi, Elia; Mariotto, Sara; Mancinelli, Chiara; Farinazzo, Alessia; Alberti, Daniela; Gajofatto, Alberto; Ferrari, Sergio; Capra, Ruggero; Monaco, Salvatore; Sechi, Gianpietro; Sechi, Leonardo A

Titolo:

Mycobacterium avium subspecies paratuberculosis and myelin basic protein specific epitopes are highly recognized by sera from patients with Neuromyelitis optica spectrum disorder

Anno:

2018

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Journal of Neuroimmunology

ISSN Rivista:

0165-5728

N° Volume:

318

Intervallo pagine:

97-102

Parole chiave:

AQP4; Epstein-Barr virus; IRF5; MBP; Mycobacterium avium subsp. paratuberculosis; neuromyelitis optica spectrum disorder

Breve descrizione dei contenuti:

Epstein-Barr virus (EBV) is the main environmental agent associated to neuromyelitis optica spectrum disorder (NMOSD). Following to studies reporting an increased prevalence of antibodies against peptides derived from Mycobacterium avium subsp. paratuberculosis (MAP) homologous to EBV and human epitopes (MBP85-98, IRF5424-434) in multiple sclerosis (MS), we investigated whether seroreactivity to these antigens display a NMOSD-specific pattern. The sera of 34 NMOSD patients showed elevated levels of antibodies against MAP and MBP compared to healthy controls (44% vs. 5%, p < 0.0002 and 50% vs. 2%, p < 0.0001, respectively), while, unlike in MS, responsiveness to EBV was similar.

Pagina Web:

https://doi.org/10.1016/j.jneuroim.2018.02.013

Id prodotto:

101650

Handle IRIS:

11562/976191

ultima modifica:

1 aprile 2023

Citazione bibliografica:

Bo, Marco; Niegowska, Magdalena; Arru, Giannina; Sechi, Elia; Mariotto, Sara; Mancinelli, Chiara; Farinazzo, Alessia; Alberti, Daniela; Gajofatto, Alberto; Ferrari, Sergio; Capra, Ruggero; Monaco, Salvatore; Sechi, Gianpietro; Sechi, Leonardo A, Mycobacterium avium subspecies paratuberculosis and myelin basic protein specific epitopes are highly recognized by sera from patients with Neuromyelitis optica spectrum disorder «Journal of Neuroimmunology» , vol. 318 , 2018 , pp. 97-102

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