Pubblicazioni

Autori:

Bertella, Enrica; Banfi, Paolo; Paneroni, Mara; Grilli, Silvia; Bianchi, Luca; Volpato, Eleonora; Vitacca, Michele

Titolo:

Early initiation of night-time NIV in an outpatient setting: a randomized non-inferiority study in ALS patients

Anno:

2017

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE

ISSN Rivista:

1973-9095

N° Volume:

53

Numero o Fascicolo:

6

Intervallo pagine:

892-899

Parole chiave:

Amyotrophic lateral sclerosis; Home care services; Noninvasive ventilation; Patient compliance

Breve descrizione dei contenuti:

BACKGROUND: In patients with amyotrophic lateral sclerosis (ALS), non-invasive ventilation (NIV) is usually initiated in an in-hospital regime. AIM: We investigated if NIV initiated in an outpatient setting can be as effective in terms of patients' acceptance/adherence. We also evaluated factors predicting NIV acceptance and adherence and disease progression. DESIGN: Prospective randomized study. SETTING: Outpatient versus inpatient rehabilitation. POPULATION : ALS patients. METHODS: ALS patients were randomized to two groups for NIV initiation: outpatients versus inpatients. At baseline (T0), end of NIV trial program (T1) and after 3 months from T1 (T2), respiratory function tests, blood gas analysis, and sleep study were performed. At T1, we assessed: NIV acceptance (>4 h/night), and dyspnea symptoms (day/night) by Visual analogue scale (VAS), staff and patients' experience (how difficult NIV was to accept, how difficult ventilator was to manage, satisfaction); at T2: NIV adherence (>120 h/month) and patients' experience. RESULTS : Fifty patients participated. There were no differences in acceptance failure (P=0.733) or adherence failure (P=0.529). At T1, outpatients had longer hours of nocturnal ventilation (P<0.02), at T2 this was similar (P=0.34). Female gender and spinal onset of the disease were predictors for NIV acceptance/adherence failure. There were no between-group differences in progression of respiratory impairment, symptoms and sleep quality.CONCLUSIONS: Early outpatient initiation of NIV in ALS is as effective as inpatient initiation.

Id prodotto:

105368

Handle IRIS:

11562/988107

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Bertella, Enrica; Banfi, Paolo; Paneroni, Mara; Grilli, Silvia; Bianchi, Luca; Volpato, Eleonora; Vitacca, Michele, Early initiation of night-time NIV in an outpatient setting: a randomized non-inferiority study in ALS patients «EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE» , vol. 53 , n. 6 , 2017 , pp. 892-899

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