Pubblicazioni

Autori:

Pedrinolla, Anna; Tamburin, Stefano; Brasioli, Anna; Sollima, Alessio; Fonte, Cristina; Muti, Ettore; Smania, Nicola; Schena, Federico; Venturelli, Massimo

Titolo:

An indoor therapeutic garden for behavioral symptoms in Alzheimer's Disease: a randomized controlled trial

Anno:

2019

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

JOURNAL OF ALZHEIMER'S DISEASE

ISSN Rivista:

1387-2877

N° Volume:

71

Numero o Fascicolo:

3

Intervallo pagine:

813-823

Parole chiave:

Alzheimer’s disease; behavioral symptoms; cortisol; gardens; non-pharmacological treatment

Breve descrizione dei contenuti:

BACKGROUND: Behavioral and psychological symptoms of dementia (BPSD) affect 60-90% of patients with Alzheimer's disease (AD). OBJECTIVE: To determine if environmental therapy is an effective strategy to reduce BPSD, we tested 163 patients with AD with Neuropsychiatric Inventory (NPI) before and after 6 months of an indoor therapeutic garden (TG) or standard environment. METHODS: A single-blind randomized controlled trial on AD patients with BPSD. Participants were randomized to an indoor TG (N = 82), or standard environment (control, N = 81) for 6 months. PRIMARY OUTCOME: change in the NPI score from baseline (T0) to end of treatment (T1). SECONDARY OUTCOMES: change in use of quetiapine, cognition, activities of daily living, salivary cortisol, blood pressure from T0 to T1. RESULTS: NPI score significantly ameliorated (TG versus control: -31.8 points), quetiapine dosage (-150 mg), blood pressure (-2.6 mm Hg), and salivary cortisol (-6.4 to -2.1 Nmol/l) were significantly reduced, the Mini-Mental State Examination significantly improved (1.8 points) in the TG versus control arm at T1 (p < 0.001). No adverse events were reported. CONCLUSION: The indoor TG seems safe and may reduce BPSD, medication intake, and cortisol levels in AD.

Pagina Web:

https://doi.org/10.3233/JAD-190394

Id prodotto:

109989

Handle IRIS:

11562/999269

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Pedrinolla, Anna; Tamburin, Stefano; Brasioli, Anna; Sollima, Alessio; Fonte, Cristina; Muti, Ettore; Smania, Nicola; Schena, Federico; Venturelli, Massimo, An indoor therapeutic garden for behavioral symptoms in Alzheimer's Disease: a randomized controlled trial «JOURNAL OF ALZHEIMER'S DISEASE» , vol. 71 , n. 3 , 2019 , pp. 813-823

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